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J Neurophysiol 83: 3169-3172, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3169-3172
Copyright ©2000 by the American Physiological Society

RAPID COMMUNICATION

Equilibrium Potential of GABAA Current and Implications for Rebound Burst Firing in Rat Subthalamic Neurons In Vitro

Mark D. Bevan,1,2 Charles J. Wilson,2,3 J. Paul Bolam,1 and Peter J. Magill1

 1Medical Research Council Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford OX1 3TH, United Kingdom;  2Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163; and  3Division of Life Science, University of Texas, San Antonio, Texas 78294

Bevan, Mark D., Charles J. Wilson, J. Paul Bolam, and Peter J. Magill. Equilibrium Potential of GABAA Current and Implications for Rebound Burst Firing in Rat Subthalamic Neurons In Vitro. J. Neurophysiol. 83: 3169-3172, 2000. Reciprocally connected glutamatergic subthalamic and GABAergic globus pallidus neurons have recently been proposed to act as a generator of low-frequency oscillatory activity in Parkinson's disease. To determine whether GABAA receptor-mediated synaptic potentials could theoretically generate rebound burst firing in subthalamic neurons, a feature that is central to the proposed oscillatory mechanism, we determined the equilibrium potential of GABAA current (EGABAA) and the degree of hyperpolarization required for rebound firing using perforated-patch recording. In the majority of neurons that fired rebounds, EGABAA was equal to or more hyperpolarized than the hyperpolarization required for rebound burst firing. These data suggest that synchronous activity of pallidal inputs could underlie rhythmic bursting activity of subthalamic neurons in Parkinson's disease.




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