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The Journal of Neurophysiology Vol. 83 No. 5 May 2000, pp. 3177-3182
Copyright ©2000 by the American Physiological Society
RAPID COMMUNICATION
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
Williams, Stephen R. and
Greg J. Stuart.
Site Independence of EPSP Time Course Is Mediated by Dendritic
Ih in Neocortical Pyramidal Neurons. J. Neurophysiol. 83: 3177-3182, 2000. Neocortical layer 5 pyramidal neurons possess long apical dendrites
that receive a significant portion of the neurons excitatory synaptic
input. Passive neuronal models indicate that the time course of
excitatory postsynaptic potentials (EPSPs) generated in the apical
dendrite will be prolonged as they propagate toward the soma. EPSP
propagation may, however, be influenced by the recruitment of dendritic
voltage-activated channels. Here we investigate the properties and
distribution of Ih channels in the axon,
soma, and apical dendrites of neocortical layer 5 pyramidal neurons, and their effect on EPSP time course. We find a linear increase (9 pA/100 µm) in the density of dendritic Ih
channels with distance from soma. This nonuniform distribution of
Ih channels generates site independence of
EPSP time course, such that the half-width at the soma of distally
generated EPSPs (up to 435 µm from soma) was similar to somatically
generated EPSPs. As a corollary, a normalization of temporal summation
of EPSPs was observed. The site independence of somatic EPSP time
course was found to collapse after pharmacological blockade of
Ih channels, revealing pronounced temporal
summation of distally generated EPSPs, which could be further enhanced
by TTX-sensitive sodium channels. These data indicate that an
increasing density of apical dendritic Ih
channels mitigates the influence of cable filtering on somatic EPSP
time course and temporal summation in neocortical layer 5 pyramidal neurons.
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