JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 84: 236-246, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, T.
Right arrow Articles by Wang, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, T.
Right arrow Articles by Wang, X.

The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 236-246
Copyright ©2000 by the American Physiological Society

Temporal Discharge Patterns Evoked by Rapid Sequences of Wide- and Narrowband Clicks in the Primary Auditory Cortex of Cat

Thomas Lu and Xiaoqin Wang

Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Lu, Thomas and Xiaoqin Wang. Temporal Discharge Patterns Evoked by Rapid Sequences of Wide- and Narrowband Clicks in the Primary Auditory Cortex of Cat. J. Neurophysiol. 84: 236-246, 2000. The present study investigated neural responses to rapid, repetitive stimuli in the primary auditory cortex (A1) of cats. We focused on two important issues regarding cortical coding of sequences of stimuli: temporal discharge patterns of A1 neurons as a function of inter-stimulus interval and cortical mechanisms for representing successive stimulus events separated by very short intervals. These issues were studied using wide- and narrowband click trains with inter-click intervals (ICIs) ranging from 3 to 100 ms as a class of representative sequential stimuli. The main findings of this study are 1) A1 units displayed, in response to click train stimuli, three distinct temporal discharge patterns that we classify as regions I, II, and III. At long ICIs nearly all A1 units exhibited typical stimulus-synchronized response patterns (region I) consistent with previously reported observations. At intermediate ICIs, no clear temporal structures were visible in the responses of most A1 units (region II). At short ICIs, temporal discharge patterns are characterized by the presence of either intrinsic oscillations (at ~10 Hz) or a change in discharge rate that was a monotonically decreasing function of ICI (region III). In some A1 units, temporal discharge patterns corresponding to region III were absent. 2) The boundary between regions I and II (synchronization boundary) had a median value of 39.8 ms ICI ([25%, 75%] = [20.4, 58.8] ms ICI; n = 131). The median boundary between regions II and III was estimated at 6.3 ms ([25%, 75%] = [5.2, 9.7] ms ICI; n = 47) for units showing rate changes (rate-change boundary). 3) The boundary values between different regions appeared to be relatively independent of stimulus intensity (at modest sound levels) or the bandwidth of the clicks used. 4) There is a weak correlation between a unit's synchronization boundary and its response latency. Units with shorter latencies appeared to also have smaller boundary values. And 5) based on these findings, we proposed a two-stage model for A1 neurons to represent a wide range of ICIs. In this model, A1 uses a temporal code for explicitly representing long ICIs and a rate code for implicitly representing short ICIs.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
P. K. Pandya, D. L. Rathbun, R. Moucha, N. D. Engineer, and M. P. Kilgard
Spectral and Temporal Processing in Rat Posterior Auditory Cortex
Cereb Cortex, February 1, 2008; 18(2): 301 - 314.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. H. Lim, T. Lenarz, G. Joseph, R.-D. Battmer, A. Samii, M. Samii, J. F. Patrick, and M. Lenarz
Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System
J. Neurosci., December 5, 2007; 27(49): 13541 - 13551.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. L. Bartlett and X. Wang
Neural Representations of Temporally Modulated Signals in the Auditory Thalamus of Awake Primates
J Neurophysiol, February 1, 2007; 97(2): 1005 - 1017.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. L. Phan and G. H. Recanzone
Single-Neuron Responses to Rapidly Presented Temporal Sequences in the Primary Auditory Cortex of the Awake Macaque Monkey
J Neurophysiol, February 1, 2007; 97(2): 1726 - 1737.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Mickey and J. C. Middlebrooks
Sensitivity of Auditory Cortical Neurons to the Locations of Leading and Lagging Sounds
J Neurophysiol, August 1, 2005; 94(2): 979 - 989.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Lu and X. Wang
Information Content of Auditory Cortical Responses to Time-Varying Acoustic Stimuli
J Neurophysiol, January 1, 2004; 91(1): 301 - 313.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
D. L. Barbour and X. Wang
Auditory Cortical Responses Elicited in Awake Primates by Random Spectrum Stimuli
J. Neurosci., August 6, 2003; 23(18): 7194 - 7206.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. P. Harms and J. R. Melcher
Sound Repetition Rate in the Human Auditory Pathway: Representations in the Waveshape and Amplitude of fMRI Activation
J Neurophysiol, September 1, 2002; 88(3): 1433 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Liang, T. Lu, and X. Wang
Neural Representations of Sinusoidal Amplitude and Frequency Modulations in the Primary Auditory Cortex of Awake Primates
J Neurophysiol, May 1, 2002; 87(5): 2237 - 2261.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. S. Nagarajan, S. W. Cheung, P. Bedenbaugh, R. E. Beitel, C. E. Schreiner, and M. M. Merzenich
Representation of Spectral and Temporal Envelope of Twitter Vocalizations in Common Marmoset Primary Auditory Cortex
J Neurophysiol, April 1, 2002; 87(4): 1723 - 1737.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. J. Eggermont
Temporal Modulation Transfer Functions in Cat Primary Auditory Cortex: Separating Stimulus Effects From Neural Mechanisms
J Neurophysiol, January 1, 2002; 87(1): 305 - 321.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Wang and S. C. Kadia
Differential Representation of Species-Specific Primate Vocalizations in the Auditory Cortices of Marmoset and Cat
J Neurophysiol, November 1, 2001; 86(5): 2616 - 2620.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Lu, L. Liang, and X. Wang
Neural Representations of Temporally Asymmetric Stimuli in the Auditory Cortex of Awake Primates
J Neurophysiol, June 1, 2001; 85(6): 2364 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Wang
On cortical coding of vocal communication sounds in primates
PNAS, October 24, 2000; 97(22): 11843 - 11849.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online