| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 255-273
Copyright ©2000 by the American Physiological Society
Center for Neural Science, New York University, New York, New York 10003
Krishna, B. Suresh and
Malcolm N. Semple.
Auditory Temporal Processing: Responses to Sinusoidally
Amplitude-Modulated Tones in the Inferior Colliculus. J. Neurophysiol. 84: 255-273, 2000. Time-varying envelopes are a common feature of acoustic communication
signals like human speech and induce a variety of percepts in human
listeners. We studied the responses of 109 single neurons in the
inferior colliculus (IC) of the anesthetized Mongolian gerbil to
contralaterally presented sinusoidally amplitude-modulated (SAM) tones
with a wide range of parameters. Modulation transfer functions (MTFs)
based on average spike rate (rMTFs) showed regions of enhancement and
suppression, where spike rates increased or decreased respectively as
stimulus modulation depth increased. Specifically, almost all IC rMTFs
could be described by some combination of a primary and a secondary
region of enhancement and an intervening region of suppression, with
these regions present to varying degrees in individual rMTFs. rMTF
characteristics of most neurons were dependent on sound pressure level
(SPL). rMTFs in most neurons with "onset" or "onset-sustained"
peri-stimulus time histograms (PSTHs) in response to brief pure tones
showed only a peaked primary region of enhancement. The region of
suppression tended to occur in neurons with "sustained" or
"pauser" PSTHs, and usually emerged at higher SPLs. The secondary
region of enhancement was only found in eight neurons. The lowest
modulation frequency at which the spike rate reached a clear peak
("best modulation frequency" or BMF) was measured. All but two mean
BMFs lay between 0 and 100 Hz. Fifty percent of the 49 neurons tested
over at least a 20-dB range of SPLs showed a BMF variation larger than
66% of their mean BMF. MTFs based on vector strength (tMTFs) showed a
variety of patterns; although mostly similar to those reported from the cochlear nucleus, tMTFs of IC neurons showed higher maximum values, smaller dynamic range with depth, and a lower high-frequency limit for
significant phase locking. Systematic and large increases in phase-lead
commonly occurred as SPL increased. rMTFs measured at multiple carrier
frequencies (Fcs) showed that the
suppressive region was not the result of sideband inhibition. There was
no systematic relationship between BMF and
Fc of stimulation in the cells
studied, even at low carrier frequencies. The results suggest various
possible mechanisms that could create IC MTFs, and strongly support the
idea that inhibitory inputs shape the rMTF by sharpening regions of
enhancement and creating a suppressive region. The paucity of BMFs
above 100 Hz argues against simple rate-coding schemes for pitch.
Finally, any labeled line or topographic representation of modulation
frequency is unlikely to be independent of SPL.
This article has been cited by other articles:
|
|
 |
|
  J. C. Middlebrooks Auditory Cortex Phase Locking to Amplitude-Modulated Cochlear Implant Pulse Trains J Neurophysiol, July 1, 2008; 100(1): 76 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Middlebrooks Cochlear-Implant High Pulse Rate and Narrow Electrode Configuration Impair Transmission of Temporal Information to the Auditory Cortex J Neurophysiol, July 1, 2008; 100(1): 92 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Caspary, L. Ling, J. G. Turner, and L. F. Hughes Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system J. Exp. Biol., June 1, 2008; 211(11): 1781 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Lesica and B. Grothe Dynamic Spectrotemporal Feature Selectivity in the Auditory Midbrain J. Neurosci., May 21, 2008; 28(21): 5412 - 5421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Smith and B. Delgutte Sensitivity of Inferior Colliculus Neurons to Interaural Time Differences in the Envelope Versus the Fine Structure With Bilateral Cochlear Implants J Neurophysiol, May 1, 2008; 99(5): 2390 - 2407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Siveke, S. D. Ewert, B. Grothe, and L. Wiegrebe Psychophysical and Physiological Evidence for Fast Binaural Processing J. Neurosci., February 27, 2008; 28(9): 2043 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Malone, B. H. Scott, and M. N. Semple Dynamic Amplitude Coding in the Auditory Cortex of Awake Rhesus Macaques J Neurophysiol, September 1, 2007; 98(3): 1451 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, V. C. Kotak, and D. H. Sanes Conductive Hearing Loss Disrupts Synaptic and Spike Adaptation in Developing Auditory Cortex J. Neurosci., August 29, 2007; 27(35): 9417 - 9426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Tan and J.G.G. Borst Comparison of Responses of Neurons in the Mouse Inferior Colliculus to Current Injections, Tones of Different Durations, and Sinusoidal Amplitude-Modulated Tones J Neurophysiol, July 1, 2007; 98(1): 454 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ter-Mikaelian, D. H. Sanes, and M. N. Semple Transformation of Temporal Properties between Auditory Midbrain and Cortex in the Awake Mongolian Gerbil J. Neurosci., June 6, 2007; 27(23): 6091 - 6102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wohlgemuth and B. Ronacher Auditory Discrimination of Amplitude Modulations Based on Metric Distances of Spike Trains J Neurophysiol, April 1, 2007; 97(4): 3082 - 3092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Bartlett and X. Wang Neural Representations of Temporally Modulated Signals in the Auditory Thalamus of Awake Primates J Neurophysiol, February 1, 2007; 97(2): 1005 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Nelson and L. H. Carney Neural Rate and Timing Cues for Detection and Discrimination of Amplitude-Modulated Tones in the Awake Rabbit Inferior Colliculus J Neurophysiol, January 1, 2007; 97(1): 522 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and J. B. Kelly Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Amplitude-Modulated Tones J Neurophysiol, December 1, 2006; 96(6): 2905 - 2914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dreyer and B. Delgutte Phase Locking of Auditory-Nerve Fibers to the Envelopes of High-Frequency Sounds: Implications for Sound Localization J Neurophysiol, November 1, 2006; 96(5): 2327 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Batra Responses of Neurons in the Ventral Nucleus of the Lateral Lemniscus to Sinusoidally Amplitude Modulated Tones J Neurophysiol, November 1, 2006; 96(5): 2388 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Chase and E. D. Young Spike-Timing Codes Enhance the Representation of Multiple Simultaneous Sound-Localization Cues in the Inferior Colliculus J. Neurosci., April 12, 2006; 26(15): 3889 - 3898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Firzlaff, S. Schornich, S. Hoffmann, G. Schuller, and L. Wiegrebe A Neural Correlate of Stochastic Echo Imaging J. Neurosci., January 18, 2006; 26(3): 785 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. X. Joris, B. van de Sande, A. Recio-Spinoso, and M. van der Heijden Auditory Midbrain and Nerve Responses to Sinusoidal Variations in Interaural Correlation J. Neurosci., January 4, 2006; 26(1): 279 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. TRAMO, P. A. CARIANI, C. K. KOH, N. MAKRIS, and L. D. BRAIDA Neurophysiology and Neuroanatomy of Pitch Perception: Auditory Cortex Ann. N.Y. Acad. Sci., December 1, 2005; 1060(1): 148 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Sinex, H. Li, and D. S. Velenovsky Prevalence of Stereotypical Responses to Mistuned Complex Tones in the Inferior Colliculus J Neurophysiol, November 1, 2005; 94(5): 3523 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ojima, M. Takayanagi, D. Potapov, and R. Homma Isofrequency Band-like Zones of Activation Revealed by Optical Imaging of Intrinsic Signals in the Cat Primary Auditory Cortex Cereb Cortex, October 1, 2005; 15(10): 1497 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. N. Woolley and J. H. Casseday Processing of Modulated Sounds in the Zebra Finch Auditory Midbrain: Responses to Noise, Frequency Sweeps, and Sinusoidal Amplitude Modulations J Neurophysiol, August 1, 2005; 94(2): 1143 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Lane and B. Delgutte Neural Correlates and Mechanisms of Spatial Release From Masking: Single-Unit and Population Responses in the Inferior Colliculus J Neurophysiol, August 1, 2005; 94(2): 1180 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Griffin, L. R. Bernstein, N. J. Ingham, and D. McAlpine Neural Sensitivity to Interaural Envelope Delays in the Inferior Colliculus of the Guinea Pig J Neurophysiol, June 1, 2005; 93(6): 3463 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, S. H. Wu, and J. B. Kelly Regulation of Auditory Responses in the Central Nucleus of the Inferior Colliculus by Tetraethylammonium-Sensitive Potassium Channels J Neurophysiol, May 1, 2004; 91(5): 2194 - 2204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. X. JORIS, C. E. SCHREINER, and A. REES Neural Processing of Amplitude-Modulated Sounds Physiol Rev, April 1, 2004; 84(2): 541 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Kvale and C. E. Schreiner Short-Term Adaptation of Auditory Receptive Fields to Dynamic Stimuli J Neurophysiol, February 1, 2004; 91(2): 604 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Escabi, L. M. Miller, H. L. Read, and C. E. Schreiner Naturalistic Auditory Contrast Improves Spectrotemporal Coding in the Cat Inferior Colliculus J. Neurosci., December 17, 2003; 23(37): 11489 - 11504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Sterbing, W. R. D'Angelo, E.-M. Ostapoff, and S. Kuwada Effects of Amplitude Modulation on the Coding of Interaural Time Differences of Low-Frequency Sounds in the Inferior Colliculus. I. Response Properties J Neurophysiol, November 1, 2003; 90(5): 2818 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. D'Angelo, S. J. Sterbing, E.-M. Ostapoff, and S. Kuwada Effects of Amplitude Modulation on the Coding of Interaural Time Differences of Low-Frequency Sounds in the Inferior Colliculus. II. Neural Mechanisms J Neurophysiol, November 1, 2003; 90(5): 2827 - 2836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Qiu, C. E. Schreiner, and M. A. Escabi Gabor Analysis of Auditory Midbrain Receptive Fields: Spectro-Temporal and Binaural Composition J Neurophysiol, July 1, 2003; 90(1): 456 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and J. B. Kelly Glutamatergic and GABAergic Regulation of Neural Responses in Inferior Colliculus to Amplitude-Modulated Sounds J Neurophysiol, July 1, 2003; 90(1): 477 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R Palmer and A Q. Summerfield Microelectrode and neuroimaging studies of central auditory function Br. Med. Bull., October 1, 2002; 63(1): 95 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Harms and J. R. Melcher Sound Repetition Rate in the Human Auditory Pathway: Representations in the Waveshape and Amplitude of fMRI Activation J Neurophysiol, September 1, 2002; 88(3): 1433 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Escabi and C. E. Schreiner Nonlinear Spectrotemporal Sound Analysis by Neurons in the Auditory Midbrain J. Neurosci., May 15, 2002; 22(10): 4114 - 4131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. TRAMO, P. A. CARIANI, B. DELGUTTE, and L. D. BRAIDA Neurobiological Foundations for the Theory of Harmony in Western Tonal Music Ann. N.Y. Acad. Sci., June 1, 2001; 930(1): 92 - 116. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
