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The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 28-38
Copyright ©2000 by the American Physiological Society
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
Pettit, Diana L. and
George J. Augustine.
Distribution of Functional Glutamate and GABA Receptors on
Hippocampal Pyramidal Cells and Interneurons. J. Neurophysiol. 84: 28-38, 2000. The distribution of
functional neurotransmitter receptors is an important determinant of
neuronal information processing. To map the location of functional
glutamate and GABA receptors on individual hippocampal neurons, we
photolyzed "caged" glutamate and GABA while measuring the
electrical currents resulting from activation of these receptors.
Responses to uncaged neurotransmitters were spatially nonuniform and
varied according to the type of receptor and type of neuron. Every
region of CA1 pyramidal cells responded to glutamate and GABA, but
glutamate and GABA receptors increased in density along the length of
their distal dendrites. Similar gradients of glutamate receptors were
found in stratum radiatum interneurons, while GABA responses were
detectable only in the perisomatic region of these interneurons. These
regional variations in receptor distribution indicate the selective
targeting of receptors on central neurons and may reflect a mechanism
for local regulation of synaptic efficacy.
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