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The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 301-310
Copyright ©2000 by the American Physiological Society
Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland 20892-4435
Powell, Keith D. and
Michael E. Goldberg.
Response of Neurons in the Lateral Intraparietal Area to a
Distractor Flashed During the Delay Period of a Memory-Guided Saccade. J. Neurophysiol. 84: 301-310, 2000. Recent experiments raised the possibility that the lateral
intraparietal area (LIP) might be specialized for saccade planning. If
this was true, one would expect a decreased sensitivity to irrelevant
visual stimuli appearing late in the delay period of a memory-guided
delayed-saccade task to a target outside the neurons' receptive
fields. We trained two monkeys to perform a standard memory-guided
delayed-saccade task and a distractor task in which a stimulus flashed
for 200 ms at a predictable time 300-100 ms before the end of the
delay period. We used two locations, one in the most active part of the
receptive field and another well outside the receptive field. We used
six kinds of trials randomly intermixed: simple delayed-saccade trials
into or away from the receptive field and distractor trials with
saccade target and distractor both in the receptive field, both out of
the receptive field, or one at each location. This enabled us to study
the response to the distractor as a function of the monkey's
preparation of a memory-guided delayed-saccade task. We had assumed
that the preparation of a saccade away from the receptive field would
result in an attenuation of the response to the distractor, i.e., a
distractor at the location of the saccade goal would evoke a greater
response than when it appeared at a location far from the saccade goal. Instead we found that neurons exhibited either a normal or an enhanced
visual response to the distractor during the memory period when the
target flashed outside the receptive field. When the distractor flashed
at the location of the saccade target, the response to the distractor
was either unchanged or diminished. The response to a distractor away
from the target location of a memory-guided saccade was even greater
than the response to the same target when it was the target for the
memory-guided saccade task. Immediate presaccadic activity did not
distinguish between a saccade to the receptive field when there was no
distractor and a distractor in the receptive field when the monkey made
a saccade elsewhere. Nonetheless the distractor had no significant effect on the saccade latency, accuracy, or velocity despite the brisk
response it evoked immediately before the saccade. We suggest that
these results are inconsistent with a role for LIP in the specific
generation of saccades, but they are consistent with a role for LIP in
the generation of visual attention.
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