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The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 451-459
Copyright ©2000 by the American Physiological Society
Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Asaad, Wael F.,
Gregor Rainer, and
Earl K. Miller.
Task-Specific Neural Activity in the Primate Prefrontal Cortex. J. Neurophysiol. 84: 451-459, 2000. Real-world behavior is typically more complicated than a one-to-one
mapping between a stimulus and response; the same stimulus can lead to
different behaviors depending on the situation, or the same behavior
may be cued by different stimuli. In such cases, knowledge of the
formal demands of the task at hand is required. We found that in
monkeys trained to alternate between three tasks, the activity of many
neurons in the prefrontal cortex was task dependent. This included
changes in overall firing rate, in firing-rate profiles (shape of
responses over time), and in stimulus and response selectivity. These
findings support the hypothesis that a major prefrontal function is the
acquisition and implementation of task context and the "rules" used
to guide behavior.
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