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The Journal of Neurophysiology Vol. 84 No. 1 July 2000, pp. 570-574
Copyright ©2000 by the American Physiological Society
Departments of 1Physiology and 2Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Dostrovsky, J. O.,
R. Levy,
J. P. Wu,
W. D. Hutchison,
R. R. Tasker, and
A. M. Lozano.
Microstimulation-Induced Inhibition of Neuronal Firing in Human
Globus Pallidus. J. Neurophysiol. 84: 570-574, 2000. Neurosurgical treatment of Parkinson's disease (PD)
frequently employs chronic high-frequency deep brain stimulation (DBS) within the internal segment of globus pallidus (GPi) and can very effectively reduce L-dopa-induced dyskinesias and bradykinesia, but
the mechanisms are unknown. The present study examined the effects of
microstimulation in GPi on the activity of neurons close to the
stimulation site. Recordings were made from GPi using two fixed or
independently controlled microelectrodes, with the electrode tips
usually ~250 or >600 µm apart in PD patients undergoing stereotactic exploration to localize the optimal site for placement of
a lesion or DBS electrode. The spontaneous activity of nearly all of
the cells (22/23) recorded in GPi in three patients was inhibited by
microstimulation at currents typically <10 µA (0.15-ms pulses at 5 Hz). The inhibition had a duration of 10-25 ms at threshold. These
findings suggest that microstimulation within GPi preferentially
excites the axon terminals of striatal and/or external pallidal neurons
causing release of GABA and inhibition of GPi neurons.
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