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The Journal of Neurophysiology Vol. 84 No. 2 August 2000, pp. 1012-1025
Copyright ©2000 by the American Physiological Society
Section of Neurobiology, Physiology and Behavior and Center for Neuroscience, University of California, Davis, California 95616
Sutter, Mitchell L.
Shapes and Level Tolerances of Frequency Tuning Curves in
Primary Auditory Cortex: Quantitative Measures and Population Codes. J. Neurophysiol. 84: 1012-1025, 2000. The shape and level tolerance of the excitatory frequency/intensity
tuning curves (eFTCs) of 160 cat primary auditory cortical (A1) neurons
were investigated. Overall, A1 cells were characterized by tremendous
variety in eFTC shapes and symmetries; eFTCs were U-shaped (~20%),
V-shaped (~20%), lower-tail-upper-sharp (~15%), upper-tail-lower-sharp (<2%), slant-lower (~10%), slant-upper (<3%), multipeaked (~10%), and circumscribed (~20%).
Quantitative analysis suggests that eFTC are best thought of as forming
a continuum of shapes, rather than falling into discrete categories. A1
eFTCs tended to be more level tolerant than eFTCs from earlier stations in the ascending auditory system as inferred from other studies. While
individual peaks of multipeaked eFTCs were similar to single peaked
eFTCs, the overall eFTC of multipeaked neurons (spanning the range of
all peaks) tended to have high-frequency tails. Measurements of shape
and symmetry indicate that A1 eFTCs, on average, tended to have greater
area on the low-frequency side of characteristic frequency (CF) than on
the high-frequency side. A1 cells showed a relationship between CF and
the inverse slope of low-frequency edges of eFTCs, but not for
high-frequency edges. These data demonstrate that frequency tuning,
particularly along the eFTC low-frequency border, sharpens along the
lemniscal pathway to A1. The results are consistent with studies in
mustached bats (Suga 1997) and support the idea that
spectral decomposition along the ascending lemniscal pathway up to A1
is a general organizing principle of mammalian auditory systems.
Altogether, these data suggest that A1 neurons' eFTCs are shaped by
complex patterns of inhibition and excitation accumulating along the
auditory pathways, implying that central rather than peripheral
filtering properties are responsible for certain psychophysical phenomena.
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