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J Neurophysiol 84: 719-729, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 84 No. 2 August 2000, pp. 719-729
Copyright ©2000 by the American Physiological Society

Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory Cortex

Dan R. Kenshalo,1,2 Koichi Iwata,3 Maurice Sholas,4 and David A. Thomas

 1Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research and  2The Center for Scientific Review, National Institutes of Health, Bethesda, Maryland 20892;  3Department of Physiology, Nihon University School of Dentistry, Tokyo 101, Japan; and  4Program in Neuroscience, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts 20115

Kenshalo, Dan R., Koichi Iwata, Maurice Sholas, and David A. Thomas. Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory Cortex. J. Neurophysiol. 84: 719-729, 2000. The organization and response properties of nociceptive neurons in area 1 of the primary somatosensory cortex (SI) of anesthetized monkeys were examined. The receptive fields of nociceptive neurons were classified as either wide-dynamic-range (WDR) neurons that were preferentially responsive to noxious mechanical stimulation, or nociceptive specific (NS) that were responsive to only noxious stimuli. The cortical locations and the responses of the two classes of neurons were compared. An examination of the neuronal stimulus-response functions obtained during noxious thermal stimulation of the glabrous skin of the foot or the hand indicated that WDR neurons exhibited significantly greater sensitivity to noxious thermal stimuli than did NS neurons. The receptive fields of WDR neurons were significantly larger than the receptive fields of NS neurons. Nociceptive SI neurons were somatotopically organized. Nociceptive neurons with receptive fields on the foot were located more medial in area 1 of SI than those with receptive fields on the hand. In the foot representation, the recording sites of nociceptive neurons were near the boundary between areas 3b and 1, whereas in the hand area, there was a tendency for them to be located more caudal in area 1. The majority of nociceptive neurons were located in the middle layers (III and IV) of area 1. The fact that nociceptive neurons were not evenly distributed across the layers of area 1 suggested that columns of nociceptive neurons probably do not exist in the somatosensory cortex. In electrode tracks where nociceptive neurons were found, approximately half of all subsequently isolated neurons were also classified as nociceptive. Low-threshold mechanoreceptive (LTM) neurons were intermingled with nociceptive neurons. Both WDR and NS neurons were found in close proximity to one another. In instances where the receptive field shifted, subsequently isolated cells were also classified as nociceptive. These data suggest that nociceptive neurons in area 1 of SI are organized in vertically orientated aggregations or clusters in layers III and IV.




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