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J Neurophysiol 84: 1256-1265, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 84 No. 3 September 2000, pp. 1256-1265
Copyright ©2000 by the American Physiological Society

The Open- and Closed-Loop Gain-Characteristics of the Cone/Horizontal Cell Synapse in Goldfish Retina

D. A. Kraaij,1 H. Spekreijse,2 and M. Kamermans1

 1Research Unit Retinal Signal Processing, The Netherlands Ophthalmic Research Institute, and  2Department of Visual System Analysis, Graduate School Neurosciences Amsterdam, Academic Medical Center, University of Amsterdam, 1105 BA Amsterdam, The Netherlands

Kraaij, D. A., H. Spekreijse, and M. Kamermans. The Open- and Closed-Loop Gain-Characteristics of the Cone/Horizontal Cell Synapse in Goldfish Retina. J. Neurophysiol. 84: 1256-1265, 2000. Under constant light-adapted conditions, vision seems to be rather linear. However, the processes underlying the synaptic transmission between cones and second-order neurons (bipolar cells and horizontal cells) are highly nonlinear. In this paper, the gain-characteristics of the transmission from cones to horizontal cells and from horizontal cells to cones are determined with and without negative feedback from horizontal cells to cones. It is shown that 1) the gain-characteristic from cones to horizontal cells is strongly nonlinear without feedback from horizontal cells, 2) the gain-characteristic between cones and horizontal cells becomes linear when feedback is active, and 3) horizontal cells feed back to cones via a linear mechanism. In a quantitative analysis, it will be shown that negative feedback linearizes the synaptic transmission between cones and horizontal cells. The physiological consequences are discussed.




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