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J Neurophysiol 84: 1385-1391, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 84 No. 3 September 2000, pp. 1385-1391
Copyright ©2000 by the American Physiological Society

17-beta -Estradiol Modulation of Area Postrema Potassium Currents

Zhicheng Li and Meredith Hay

Dalton Cardiovascular Research Center, Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211

Li, Zhicheng and Meredith Hay. 17-beta -Estradiol Modulation of Area Postrema Potassium Currents. J. Neurophysiol. 84: 1385-1391, 2000. The purpose of this study was to determine the effects of 17-beta -estradiol on area postrema neuronal activity in vivo and on area postrema potassium currents (IK) in vitro. In anesthetized rats, intravenous injection of 17-beta -estradiol (10 ng/kg bw) -inhibited area postrema neuronal activity in 8/8 neurons tested. The averaged firing rate decreased from 2.9 ± 1.1 to 1.1 ± 0.3 Hz. The inhibitory effects of 17-beta -estradiol on area postrema neuronal activity were rapid in onset (within 1 min) and long-lasting (>8 min). To study the cellular mechanisms involved in this response, the effects of 17-beta -estradiol were examined in dissociated area postrema neurons. In these cells, 17-beta -estradiol (0.5 nM) increased the averaged peak IK 27 ± 8%. The time course for the potentiation was observed within ~0.5-1 min after the application of 17-beta -estradiol. Full recovery from the potentiation usually occurred within ~3-4 min after the washout of 17-beta -estradiol. The biologically inactive 17-alpha -estradiol had no effect on area postrema IK and the 17-beta -estradiol antagonist, ICI 182,780 blocked the effects of 17-beta -estradiol on area postrema IK. Finally, big conductance calcium-activated potassium current (MaxiK+) was identified in area postrema neurons (n = 12/12). Blockade of MaxiK+ with 100 nM iberiotoxin blocked the effects of 17-beta -estradiol on IK. These results suggested 17-beta -estradiol might modulate area postrema neuronal activity by increasing MaxiK+ current.




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