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The Journal of Neurophysiology Vol. 84 No. 3 September 2000, pp. 1422-1429
Copyright ©2000 by the American Physiological Society
1Department of Pharmacology and 2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615
Partridge, John G.,
Ka-Choi Tang, and
David M. Lovinger.
Regional and Postnatal Heterogeneity of Activity-Dependent
Long-Term Changes in Synaptic Efficacy in the Dorsal Striatum. J. Neurophysiol. 84: 1422-1429, 2000. High-frequency activation of excitatory striatal synapses produces
lasting changes in synaptic efficacy that may contribute to motor and
cognitive functions. While some of the mechanisms responsible for the
induction of long-term potentiation (LTP) and long-term depression
(LTD) of excitatory synaptic responses at striatal synapses have been
characterized, much less is known about the factors that govern the
direction of synaptic plasticity in this brain region. Here we report
heterogeneous activity-dependent changes in the direction of synaptic
strength in subregions of the developing rat striatum. Neurons in the
dorsolateral region of the anterior striatum tended to express LTD
after high-frequency afferent stimulation (HFS) in slices from animals
aged P15-P34. However, HFS in dorsolateral striatum from P12-P14
elicited an N-methyl-D-aspartate (NMDA)
receptor-dependent form of LTP. Synapses in the dorsomedial anterior
striatum exhibited a propensity to express an NMDA-receptor dependent
form of LTP across the entire developmental time period examined. The
NMDA receptor antagonist (±)-2-amino-5-phosphopentanoic acid (APV)
inhibited evoked excitatory postsynaptic potentials recorded in
striatum obtained from P12-P15 rats but had little effect in striatum
from older animals. The expression of multiple forms of synaptic
plasticity in the striatum suggests mechanisms by which this brain
region plays pivotal roles in the acquisition or encoding of some forms
of motor sequencing and stereotypical behaviors.
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