JN AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 84: 1719-1725, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gao, K.
Right arrow Articles by Mason, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, K.
Right arrow Articles by Mason, P.

The Journal of Neurophysiology Vol. 84 No. 4 October 2000, pp. 1719-1725
Copyright ©2000 by the American Physiological Society

Serotonergic Raphe Magnus Cells That Respond to Noxious Tail Heat Are Not ON or OFF Cells

Keming Gao and Peggy Mason

Department of Neurobiology, Pharmacology and Physiology and the Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637

Gao, Keming and Peggy Mason. Serotonergic Raphe Magnus Cells That Respond to Noxious Tail Heat Are Not ON or OFF Cells. J. Neurophysiol. 84: 1719-1725, 2000. Pharmacological studies have suggested that serotonergic cells in RM contribute to both the inhibition and facilitation of spinal nociceptive transmission. Physiological studies in the medullary nucleus raphe magnus (RM) and adjacent nucleus reticularis magnocellularis have identified putative nociceptive-inhibitory OFF cells and nociceptive-facilitatory neurons ON cells by their responses to noxious thermal stimulation. The present study was designed to determine 1) whether any serotonergic RM cells respond to noxious thermal stimulation and 2) whether noxious heat-responsive serotonergic cells should be classified as ON or OFF cells. Serotonergic cells (n = 150) were identified by physiological criteria in anesthetized rats; 30 of 32 cells tested contained serotonin immunoreactivity. Noxious tail heat elicited a neuronal response in less than a quarter of the serotonergic cells. Most serotonergic cells that responded to tail heat were excited (n = 25), while a small minority of the cells tested were inhibited (n = 8). The tail heat-evoked responses of serotonergic cells were small in magnitude, averaging five to eight spikes in 10 s. Excitatory responses rarely persisted for more than 10 s, while inhibitory responses rarely persisted for more than 20 s. The tail heat-evoked responses of serotonergic cells were compared to those of non-serotonergic cells (n = 186). Non-serotonergic cells that responded to noxious tail heat had significantly greater response magnitudes, averaging 75-95 spikes in 10 s, than heat-responsive serotonergic cells. In addition, most heat-responsive non-serotonergic cells responded for at least 30 s after stimulus onset. These results demonstrate that the tail heat-evoked responses of serotonergic RM cells are qualitatively and quantitatively distinct from those of non-serotonergic ON and OFF cells. It is therefore unlikely that serotonergic RM cells, even the subpopulation that responds to noxious tail heat, share a physiological function with ON and OFF cells.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
P. Mason, K. Gao, and J. R. Genzen
Serotonergic Raphe Magnus Cell Discharge Reflects Ongoing Autonomic and Respiratory Activities
J Neurophysiol, October 1, 2007; 98(4): 1919 - 1927.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. A. Graham, A. M. Brichta, and R. J. Callister
Moving From an Averaged to Specific View of Spinal Cord Pain Processing Circuits
J Neurophysiol, September 1, 2007; 98(3): 1057 - 1063.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Budai, S. G. Khasabov, P. W. Mantyh, and D. A. Simone
NK-1 Receptors Modulate the Excitability of ON Cells in the Rostral Ventromedial Medulla
J Neurophysiol, February 1, 2007; 97(2): 1388 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. S. Brink, K. M. Hellman, A. M. Lambert, and P. Mason
Raphe Magnus Neurons Help Protect Reactions to Visceral Pain From Interruption by Cutaneous Pain
J Neurophysiol, December 1, 2006; 96(6): 3423 - 3432.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Zhang, K. T. Sykes, A. V. Buhler, and D. L. Hammond
Electrophysiological Heterogeneity of Spinally Projecting Serotonergic and Nonserotonergic Neurons in the Rostral Ventromedial Medulla
J Neurophysiol, March 1, 2006; 95(3): 1853 - 1863.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. W. Nason Jr and P. Mason
Medullary Raphe Neurons Facilitate Brown Adipose Tissue Activation
J. Neurosci., January 25, 2006; 26(4): 1190 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Mason
DECONSTRUCTING ENDOGENOUS PAIN MODULATIONS
J Neurophysiol, September 1, 2005; 94(3): 1659 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Foo and P. Mason
Movement-Related Discharge of Ventromedial Medullary Neurons
J Neurophysiol, February 1, 2005; 93(2): 873 - 883.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Baez, T. S. Brink, and P. Mason
Roles for Pain Modulatory Cells during Micturition and Continence
J. Neurosci., January 12, 2005; 25(2): 384 - 394.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. S. Brink and P. Mason
Raphe Magnus Neurons Respond to Noxious Colorectal Distension
J Neurophysiol, May 1, 2003; 89(5): 2506 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Foo and P. Mason
Discharge of Raphe Magnus ON and OFF Cells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation
J. Neurosci., March 1, 2003; 23(5): 1933 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Nalivaiko and W. W. Blessing
Potential Role of Medullary Raphe-Spinal Neurons in Cutaneous Vasoconstriction: An In Vivo Electrophysiological Study
J Neurophysiol, February 1, 2002; 87(2): 901 - 911.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online