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The Journal of Neurophysiology Vol. 84 No. 4 October 2000, pp. 1982-1987
Copyright ©2000 by the American Physiological Society
Department of Neurobiology, State University of New York at Stony Brook, Stony Brook, New York 11794
Ramcharan, E. J.,
C. L. Cox,
X.
J. Zhan,
S. M. Sherman, and
J. W. Gnadt.
Cellular Mechanisms Underlying Activity Patterns in the Monkey
Thalamus During Visual Behavior. J. Neurophysiol. 84: 1982-1987, 2000. We show for the first time
with in vitro recording that burst firing in thalamic relay cells of
the monkey is evoked by activation of voltage-dependent, low threshold
Ca2+ spikes (LTSs), as has been described in other
mammals. Due to variations in LTS amplitude, the number of
action potentials evoked by an LTS could vary between 1 and 8. These
data confirm the presence of two modes of firing in the monkey for
thalamic relay cells, tonic and burst,
the latter related to the activation of LTSs. With these details of the
cellular processes underlying burst firing, we could account for many
of the firing patterns we recorded from the lateral geniculate nucleus
of the thalamus in behaving monkeys. In particular, we found clear
evidence of burst firing during alert wakefulness, which had been
thought to occur only during sleep or certain pathological states. This
makes it likely that the burst firing seen in awake humans has the same
cellular basis of LTSs, and this supports previous suggestions that
burst firing represents an important relay mode for visual processing.
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