JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 84: 2161-2165, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Köhling, R.
Right arrow Articles by Speckmann, E.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Köhling, R.
Right arrow Articles by Speckmann, E.-J.

The Journal of Neurophysiology Vol. 84 No. 4 October 2000, pp. 2161-2165
Copyright ©2000 by the American Physiological Society

RAPID COMMUNICATION

Optical Monitoring of Neuronal Activity During Spontaneous Sharp Waves in Chronically Epileptic Human Neocortical Tissue

Rüdiger Köhling,1 Jörg-Michael Höhling,1 Heidrun Straub,1 Dieter Kuhlmann,1 Ulrich Kuhnt,2 Ingrid Tuxhorn,3 Alois Ebner,3 Peter Wolf,3 Heinz-Wolfgang Pannek,3 Ali Gorji,1 and Erwin-Josef Speckmann1

 1Institut für Physiologie, Westfälische Wilhelms-Universität, 48149 Münster;  2Max-Planck-Institut f. Biophysikalische Chemie, 37077 Göttingen; and  3Epilepsiezentrum Bethel, 33617 Bielefeld, Germany

Köhling, Rüdiger, Jörg-Michael Höhling, Heidrun Straub, Dieter Kuhlmann, Ulrich Kuhnt, Ingrid Tuxhorn, Alois Ebner, Peter Wolf, Heinz-Wolfgang Pannek, Ali Gorji, and Erwin-Josef Speckmann. Optical Monitoring of Neuronal Activity During Spontaneous Sharp Waves in Chronically Epileptic Human Neocortical Tissue. J. Neurophysiol. 84: 2161-2165, 2000. Functional changes in neuronal circuitry reflected in spontaneously occurring synchronous sharp field potentials (SSFP) have been reported to occur in human brain suffering from chronic epileptogenicity but not in primary nonepileptic tissue from peritumoral resectates. Voltage sensitive dyes and fast imaging were used to visualize spontaneously occurring rhythmic depolarizations correlated to SSFP in chronically epileptic human neocortical slices obtained during epilepsy surgery. Localized and spatially inhomogeneous neuronal depolarizations were found to underlie spontaneous SSFP, which remained unchanged and spatially restricted to foci <750 µm diam even under epileptogenic (low-Mg2+) conditions. In cases where ictaform paroxysmal activity occurred in low-Mg2+ medium, neuronal depolarizations were wide-spread but still spatially inhomogeneous, and the events were preferentially initiated at distinct foci. The findings suggest that small neuronal networks are able to establish and maintain synchronous rhythmic and epileptiform activity.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online