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The Journal of Neurophysiology Vol. 84 No. 5 November 2000, pp. 2204-2216
Copyright ©2000 by the American Physiological Society
Centre de Recherche Fernand-Seguin and Department of Psychiatry, University of Montréal, Montreal, Quebec H1N 3V2, Canada
Belleau, Marc L. and
Richard A. Warren.
Postnatal Development of Electrophysiological Properties of
Nucleus Accumbens Neurons. J. Neurophysiol. 84: 2204-2216, 2000. We have studied the postnatal development
of the physiological characteristics of nucleus accumbens (nAcb)
neurons in slices from postnatal day 1 (P1) to
P49 rats using the whole cell patch-clamp technique. The
majority of neurons (102/108) were physiologically identified as medium
spiny (MS) projection neurons, and only these were subjected to
detailed analysis. The remaining neurons displayed characteristics
suggesting that they were not MS neurons. Around the time of birth and
during the first postnatal weeks, the membrane and firing
characteristics of MS neurons were quite different from those observed
later. These characteristics changed rapidly during the first 3 postnatal weeks, at which point they began to resemble those found in
adults. Both whole cell membrane resistance and membrane time constant
decreased more than fourfold during the period studied. The resting
membrane potential (RMP) also changed significantly from an average of
50 mV around birth to less than 80 mV by the end of the third
postnatal week. During the first postnatal week, the current-voltage
relationship of all encountered MS neurons was linear over a wide range
of membrane potentials above and below RMP. Through the second
postnatal week, the proportion of neurons displaying inward
rectification in the hyperpolarized range increased steadily and after
P15, all recorded MS neurons displayed significant inward
rectification. At all ages, inward rectification was blocked by
extracellular cesium and tetra-ethyl ammonium and was not changed by
4-aminopyridine; this shows that inward rectification was mediated by
the same currents in young and mature MS neurons. MS neurons fired
single and repetitive
Na+/K+ action potentials as
early as P1. Spike threshold and amplitude remained constant
throughout development in contrast to spike duration, which decreased
significantly over the same period. Depolarizing current pulses from
rest showed that immature MS neurons fired action potentials more
easily than their older counterparts. Taken together, the results from
the present study suggest that young and adult nAcb MS neurons
integrate excitatory synaptic inputs differently because of differences
in their membrane and firing properties. These findings provide
important insights into signal processing within nAcb during this
critical period of development.
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