JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 84: 2237-2256, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsuyama, K.
Right arrow Articles by Drew, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsuyama, K.
Right arrow Articles by Drew, T.

The Journal of Neurophysiology Vol. 84 No. 5 November 2000, pp. 2237-2256
Copyright ©2000 by the American Physiological Society

Vestibulospinal and Reticulospinal Neuronal Activity During Locomotion in the Intact Cat. I. Walking on a Level Surface

Kiyoji Matsuyama1 and Trevor Drew2

 1Laboratory of Neurobiology, National Institute for Physiological Sciences, Okazaki 444, Japan; and  2Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec H3C 3J7, Canada

Matsuyama, Kiyoji and Trevor Drew. Vestibulospinal and Reticulospinal Neuronal Activity During Locomotion in the Intact Cat. I. Walking on a Level Surface. J. Neurophysiol. 84: 2237-2256, 2000. To examine the function of descending brain stem pathways in the control of locomotion, we have characterized the discharge patterns of identified vestibulo- and reticulospinal neurons (VSNs and RSNs, respectively) recorded from the lateral vestibular nucleus (LVN) and the medullary reticular formation (MRF), during treadmill walking. Data during locomotion were obtained for 44 VSNs and for 63 RSNs. The discharge frequency of most VSNs (42/44) was phasically modulated in phase with the locomotor rhythm and the averaged peak discharge frequency ranged from 41 to 165 Hz (mean = 92.8 Hz). We identified three classes of VSNs based on their discharge pattern. Type A, or double peak, VSNs (20/44 neurons, 46%) showed two peaks and two troughs of activity in each step cycle. One of the peaks was time-locked to the activity of extensor muscles in the ipsilateral hindlimb while the other occurred anti-phase to this period of activity. Type B, or single pause, neurons (13/44 neurons, 30%) were characterized by a tonic or irregular discharge that was interrupted by a single pronounced and brief period of decreased activity that occurred just before the onset of swing in the ipsilateral hindlimb; some type B VSNs also exhibited a brief pulse of activity just preceding this decrease. Type C, or single peak, neurons (9/44 neurons, 23%) exhibited a single period of increased activity that, in most cells, was time-locked to the burst of activity of either extensor or flexor muscles of a single limb. The population of RSNs that we recorded included neurons that showed phasic activity related to the activity of flexor or extensor muscles [electromyographically (EMG) related, 26/63, 41%], those that were phasically active but whose activity was not time-locked to the activity of any of the recorded muscles (13/63, 21%) and those that were completely unrelated to locomotion (24/63, 38%). Most of the EMG-related RSNs showed one (15/26) or two (11/26) clear phasic bursts of activity that were temporally related to either flexor or extensor muscles. The discharge pattern of double-burst RSNs covaried with ipsilateral and contralateral flexor muscles. Peak averaged discharge activity in these EMG-related RSNs ranged from 4 to 98 Hz (mean = 35.2 Hz). We discuss the possibility that most VSNs regulate the overall activity of extensor muscles in the four limbs while RSNs provide a more specific signal that has the flexibility to modulate the activity of groups of flexor and extensor muscles, in either a single or in multiple limbs.




This article has been cited by other articles:


Home page
 PhysiologyHome page
S. Rossignol, G. Barriere, O. Alluin, and A. Frigon
Re-expression of Locomotor Function After Partial Spinal Cord Injury
Physiology, April 1, 2009; 24(2): 127 - 139.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Schepens, P. Stapley, and T. Drew
Neurons in the Pontomedullary Reticular Formation Signal Posture and Movement Both as an Integrated Behavior and Independently
J Neurophysiol, October 1, 2008; 100(4): 2235 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Grande, T. V. Bui, and P. K. Rose
Effect of localized innervation of the dendritic trees of feline motoneurons on the amplification of synaptic input: a computational study
J. Physiol., September 1, 2007; 583(2): 611 - 630.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. L. Kline, B. D. Schmit, and D. G. Kamper
Exaggerated interlimb neural coupling following stroke
Brain, January 1, 2007; 130(1): 159 - 169.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Schepens and T. Drew
Descending Signals From the Pontomedullary Reticular Formation Are Bilateral, Asymmetric, and Gated During Reaching Movements in the Cat
J Neurophysiol, November 1, 2006; 96(5): 2229 - 2252.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. Rossignol
Plasticity of connections underlying locomotor recovery after central and/or peripheral lesions in the adult mammals
Phil Trans R Soc B, September 29, 2006; 361(1473): 1647 - 1671.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
T. G. Deliagina, G. N. Orlovsky, P. V. Zelenin, and I. N. Beloozerova
Neural Bases of Postural Control
Physiology, June 1, 2006; 21(3): 216 - 225.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. F. Lyalka, P. V. Zelenin, A. Karayannidou, G. N. Orlovsky, S. Grillner, and T. G. Deliagina
Impairment and Recovery of Postural Control in Rabbits With Spinal Cord Lesions
J Neurophysiol, December 1, 2005; 94(6): 3677 - 3690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. R. Bent, J. T. Inglis, and B. J. McFadyen
When is Vestibular Information Important During Walking?
J Neurophysiol, September 1, 2004; 92(3): 1269 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. G. Davidson and J. A. Buford
Motor Outputs From the Primate Reticular Formation to Shoulder Muscles as Revealed by Stimulus-Triggered Averaging
J Neurophysiol, July 1, 2004; 92(1): 83 - 95.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
J. L Ruhland and P. L. van Kan
Medial Pontine Hemorrhagic Stroke
Physical Therapy, June 1, 2003; 83(6): 552 - 566.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. D. Prentice and T. Drew
Contributions of the Reticulospinal System to the Postural Adjustments Occurring During Voluntary Gait Modifications
J Neurophysiol, February 1, 2001; 85(2): 679 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Matsuyama and T. Drew
Vestibulospinal and Reticulospinal Neuronal Activity During Locomotion in the Intact Cat. II. Walking on an Inclined Plane
J Neurophysiol, November 1, 2000; 84(5): 2257 - 2276.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online