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The Journal of Neurophysiology Vol. 84 No. 5 November 2000, pp. 2398-2408
Copyright ©2000 by the American Physiological Society
Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208
Staff, Nathan P.,
Hae-Yoon Jung,
Tara Thiagarajan,
Michael Yao, and
Nelson Spruston.
Resting and Active Properties of Pyramidal Neurons in Subiculum
and CA1 of Rat Hippocampus. J. Neurophysiol. 84: 2398-2408, 2000. Action potentials are the end product of
synaptic integration, a process influenced by resting and active
neuronal membrane properties. Diversity in these properties contributes
to specialized mechanisms of synaptic integration and action potential
firing, which are likely to be of functional significance within neural circuits. In the hippocampus, the majority of subicular pyramidal neurons fire high-frequency bursts of action potentials, whereas CA1
pyramidal neurons exhibit regular spiking behavior when subjected to
direct somatic current injection. Using patch-clamp recordings from
morphologically identified neurons in hippocampal slices, we analyzed
and compared the resting and active membrane properties of pyramidal
neurons in the subiculum and CA1 regions of the hippocampus. In
response to direct somatic current injection, three subicular firing
types were identified (regular spiking, weak bursting, and strong
bursting), while all CA1 neurons were regular spiking. Within subiculum
strong bursting neurons were found preferentially further away from the
CA1 subregion. Input resistance (RN),
membrane time constant (
m), and depolarizing
"sag" in response to hyperpolarizing current pulses were similar in
all subicular neurons, while RN and
m were significantly larger in CA1 neurons.
The first spike of all subicular neurons exhibited similar action
potential properties; CA1 action potentials exhibited faster rising
rates, greater amplitudes, and wider half-widths than subicular action
potentials. Therefore both the resting and active properties of CA1
pyramidal neurons are distinct from those of subicular neurons, which
form a related class of neurons, differing in their propensity to
burst. We also found that both regular spiking subicular and CA1
neurons could be transformed into a burst firing mode by application of
a low concentration of 4-aminopyridine, suggesting that in both
hippocampal subfields, firing properties are regulated by a slowly
inactivating, D-type potassium current. The ability of all subicular
pyramidal neurons to burst strengthens the notion that they form a
single neuronal class, sharing a burst generating mechanism that is
stronger in some cells than others.
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