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The Journal of Neurophysiology Vol. 84 No. 5 November 2000, pp. 2564-2571
Copyright ©2000 by the American Physiological Society
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201
Pan, Zhuo-Hua and
Hui-Juan Hu.
Voltage-Dependent Na+ Currents in Mammalian
Retinal Cone Bipolar Cells. J. Neurophysiol. 84: 2564-2571, 2000. Voltage-dependent
Na+ channels are usually expressed in neurons
that use spikes as a means of signal coding. Retinal bipolar cells are
commonly thought to be nonspiking neurons, a category of neurons in the
CNS that uses graded potential for signal transmission. Here we report
for the first time voltage-dependent Na+ currents
in acutely isolated mammalian retinal bipolar cells with whole cell
patch-clamp recordings. Na+ currents were
observed in ~45% of recorded cone bipolar cells but not in rod
bipolar cells. Both ON and OFF cone bipolar
cells were found to express Na+ channels. The
Na+ currents were activated at membrane
potentials around 
50 to 40 mV and reached their peak around 20 to
0 mV. The half-maximal activation and steady-state inactivation
potentials were 24.7 and 68.0 mV, respectively. The time course of
recovery from inactivation could be fitted by two time constants of 6.2 and 81 ms. The amplitude of the Na+ currents
ranged from a few to >300 pA with the current density in some cells
close or comparable to that of retinal third neurons. In current-clamp
recordings, Na+-dependent action potentials were
evoked in Na+-current-bearing bipolar cells by
current injections. These findings raise the possibility that
voltage-dependent Na+ currents may play a role in
bipolar cell function.
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