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J Neurophysiol 84: 2695-2698, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 84 No. 5 November 2000, pp. 2695-2698
Copyright ©2000 by the American Physiological Society

RAPID COMMUNICATION

Adelta and C Primary Afferents Convey Dorsal Root Reflexes After Intradermal Injection of Capsaicin in Rats

Qing Lin, Xiaoju Zou, and William D. Willis

Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555-1069

Lin, Qing, Xiaoju Zou, and William D. Willis. Adelta and C Primary Afferents Convey Dorsal Root Reflexes After Intradermal Injection of Capsaicin in Rats. J. Neurophysiol. 84: 2695-2698, 2000. Antidromic activity was recorded in anesthetized rats from single afferent fibers in the proximal ends of cut dorsal root filaments at the L4-6 level and tested for responses to acute cutaneous inflammation produced by intradermal injection of capsaicin. This antidromic activity included low-frequency spontaneous firing and dorsal root reflex (DRR) discharges evoked by applying von Frey hairs to the skin of the foot. DRRs could be recorded from both small myelinated (Adelta ) and unmyelinated (C) afferent fibers, as well as from large myelinated (Abeta ) fibers. After capsaicin was injected intradermally into the plantar skin of the foot, a significant enhancement of DRR activity was seen in Adelta and C fibers but not in Abeta fibers, and this increase lasted for ~1 h. This study supports the hypothesis that centrally mediated antidromic activity in Adelta and C primary afferent fibers contributes to the development of neurogenic inflammation, presumably by release of inflammatory substances in the periphery.




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