JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 84: 2810-2820, 2000;
0022-3077/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurwitz, I.
Right arrow Articles by Weiss, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurwitz, I.
Right arrow Articles by Weiss, K. R.

The Journal of Neurophysiology Vol. 84 No. 6 December 2000, pp. 2810-2820
Copyright ©2000 by the American Physiological Society

Serotonergic and Peptidergic Modulation of the Buccal Mass Protractor Muscle (I2) in Aplysia

I. Hurwitz,1 E. C. Cropper,1 F. S. Vilim,1 V. Alexeeva,1 A. J. Susswein,2 I. Kupfermann,3 and K. R. Weiss1

 1Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029;  2Department of Life Sciences, Bar-Ilan University, Ramat-Gan 52 900, Israel; and  3Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Hurwitz, I., E. C. Cropper, F. S. Vilim, V. Alexeeva, A. J. Susswein, I. Kupfermann, and K. R. Weiss. Serotonergic and Peptidergic Modulation of the Buccal Mass Protractor Muscle (I2) in Aplysia. J. Neurophysiol. 84: 2810-2820, 2000. Plasticity of Aplysia feeding has largely been measured by noting changes in radula protraction. On the basis of previous work, it has been suggested that peripheral modulation may contribute to behavioral plasticity. However, peripheral plasticity has not been demonstrated in the neuromuscular systems that participate in radula protraction. Therefore in this study we investigated whether contractions of a major radula protraction muscle (I2) are subject to modulation. We demonstrate, first, that an increase in the firing frequency of the cholinergic I2 motoneurons will increase the amplitude of the resulting muscle contraction but will not modulate its relaxation rate. We show, second, that neuronal processes on the I2 muscle are immunoreactive to myomodulin (MM), RFamide, and serotonin (5-HT), but not to small cardioactive peptide (SCP) or buccalin. The I2 motoneurons B31, B32, B61, and B62 are not immunoreactive to RFamide, 5-HT, SCP, or buccalin. However, all four cells are MM immunoreactive and are capable of synthesizing MMa. Third, we show that the bioactivity of the different modulators is somewhat different; while the MMs (i.e., MMa and MMb) and 5-HT increase I2 muscle relaxation rate, and potentiate muscle contraction amplitude, MMa, at high concentrations, depresses muscle contractions. Fourth, our data suggest that cAMP at least partially mediates effects of modulators on contraction amplitude and relaxation rate.




This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
S. Mapara, S. Parries, C. Quarrington, K.-C. Ahn, W. J. Gallin, and J. I. Goldberg
Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis
J. Exp. Biol., March 15, 2008; 211(6): 900 - 910.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Hurwitz, A. Ophir, A. Korngreen, J. Koester, and A. J. Susswein
Currents Contributing to Decision Making in Neurons B31/B32 of Aplysia
J Neurophysiol, February 1, 2008; 99(2): 814 - 830.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-s. Wu, M. R. Due, K. Sasaki, A. Proekt, J. Jing, and K. R. Weiss
State Dependence of Spike Timing and Neuronal Function in a Motor Pattern Generating Network
J. Neurosci., October 3, 2007; 27(40): 10818 - 10831.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. M. Neustadter, R. L. Herman, R. F. Drushel, D. W. Chestek, and H. J. Chiel
The kinematics of multifunctionality: comparisons of biting and swallowing in Aplysia californica
J. Exp. Biol., January 15, 2007; 210(2): 238 - 260.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
O. R. Braubach, A. J. G. Dickinson, C. C. E. Evans, and R. P. Croll
Neural control of the velum in larvae of the gastropod, Ilyanassa obsoleta
J. Exp. Biol., December 1, 2006; 209(23): 4676 - 4689.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Katzoff, T. Ben-Gedalya, I. Hurwitz, N. Miller, Y. Z. Susswein, and A. J. Susswein
Nitric Oxide Signals That Aplysia Have Attempted to Eat, a Necessary Component of Memory Formation After Learning That Food Is Inedible
J Neurophysiol, September 1, 2006; 96(3): 1247 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Zhurov and V. Brezina
Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.
J. Neurosci., June 28, 2006; 26(26): 7056 - 7070.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Zhurov and V. Brezina
Temperature Compensation of Neuromuscular Modulation in Aplysia
J Neurophysiol, November 1, 2005; 94(5): 3259 - 3277.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Proekt, F. S. Vilim, V. Alexeeva, V. Brezina, A. Friedman, J. Jing, L. Li, Y. Zhurov, J. V. Sweedler, and K. R. Weiss
Identification of a New Neuropeptide Precursor Reveals a Novel Source of Extrinsic Modulation in the Feeding System of Aplysia
J. Neurosci., October 19, 2005; 25(42): 9637 - 9648.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Brezina, C. C. Horn, and K. R. Weiss
Modeling Neuromuscular Modulation in Aplysia. III. Interaction of Central Motor Commands and Peripheral Modulatory State for Optimal Behavior
J Neurophysiol, March 1, 2005; 93(3): 1523 - 1556.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Hurwitz, A. J. Susswein, and K. R. Weiss
Transforming Tonic Firing Into a Rhythmic Output in the Aplysia Feeding System: Presynaptic Inhibition of a Command-Like Neuron by a CPG Element
J Neurophysiol, February 1, 2005; 93(2): 829 - 842.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Brezina, I. V. Orekhova, and K. R. Weiss
Neuromuscular Modulation in Aplysia. II. Modulation of the Neuromuscular Transform in Behavior
J Neurophysiol, October 1, 2003; 90(4): 2613 - 2628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Furukawa, K. Nakamaru, K. Sasaki, Y. Fujisawa, H. Minakata, S. Ohta, F. Morishita, O. Matsushima, L. Li, V. Alexeeva, et al.
PRQFVamide, a Novel Pentapeptide Identified From the CNS and Gut of Aplysia
J Neurophysiol, June 1, 2003; 89(6): 3114 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Hurwitz, I. Kupfermann, and K. R. Weiss
Fast Synaptic Connections From CBIs to Pattern-Generating Neurons in Aplysia: Initiation and Modification of Motor Programs
J Neurophysiol, April 1, 2003; 89(4): 2120 - 2136.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. V. Orekhova, V. Alexeeva, P. J. Church, K. R. Weiss, and V. Brezina
Multiple Presynaptic and Postsynaptic Sites of Inhibitory Modulation by Myomodulin at ARC Neuromuscular Junctions of Aplysia
J Neurophysiol, March 1, 2003; 89(3): 1488 - 1502.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online