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The Journal of Neurophysiology Vol. 84 No. 6 December 2000, pp. 3036-3042
Copyright ©2000 by the American Physiological Society
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019
Wilson, Donald A.
Comparison of Odor Receptive Field Plasticity in the Rat
Olfactory Bulb and Anterior Piriform Cortex. J. Neurophysiol. 84: 3036-3042, 2000. Recent work in the anterior
piriform cortex (aPCX) has demonstrated that cortical odor receptive
fields are highly dynamic, showing rapid changes of both firing rate
and temporal patterning within relatively few inhalations of an odor,
despite relatively maintained, patterned input from olfactory bulb
mitral/tufted cells. The present experiment examined the precision
(odor-specificity) of this receptive field plasticity and compared it
with the primary cortical afferent, olfactory bulb mitral/tufted cells.
Adult Long-Evans hooded rats, urethan anesthetized and freely
breathing, were used for single-unit recording from mitral/tufted and
aPCX layer II/III neurons. Partial mapping of receptive fields to
alkane odors (pentane, heptane, and nonane) was performed before and
immediately after habituation (50-s exposure) to one of the alkanes.
The results demonstrated that odor habituation of aPCX responses was
odor specific, with minimal cross-habituation between alkanes differing by as few as two carbons. Mitral/tufted cells, however, showed strong
cross-habituation within the odor set with the most profound cross
effects to carbon chains shorter than the habituating stimulus. The
results suggest that although mitral/tufted cells and aPCX neurons have
roughly similar odor receptive fields, aPCX neurons have significantly
better odor discrimination within their receptive field. The results
have important implications for understanding the underlying bases of
receptive fields in olfactory system neurons and the mechanisms of odor
discrimination and memory.
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