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J Neurophysiol 84: 3072-3077, 2000;
0022-3077/00 $5.00
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The Journal of Neurophysiology Vol. 84 No. 6 December 2000, pp. 3072-3077
Copyright ©2000 by the American Physiological Society

RAPID COMMUNICATION

Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum

M. R. Delgado,1 L. E. Nystrom,3 C. Fissell,2 D. C. Noll,4 and J. A. Fiez1,2

 1Department of Neuroscience and  2Department of Psychology, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260;  3Department of Psychology, Princeton University, Princeton, New Jersey 08540; and  4Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109

Delgado, M. R., L. E. Nystrom, C. Fissell, D. C. Noll, and J. A. Fiez. Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum. J. Neurophysiol. 84: 3072-3077, 2000. Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback.




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