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The Journal of Neurophysiology Vol. 84 No. 6 December 2000, pp. 3088-3090
Copyright ©2000 by the American Physiological Society
RAPID COMMUNICATION
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico D.F. 07000, Mexico
Gutiérrez, Rafael
Seizures Induce Simultaneous GABAergic and Glutamatergic
Transmission in the Dentate Gyrus-CA3 System. J. Neurophysiol. 84: 3088-3090, 2000. Monosynaptic and polysynaptic
responses of CA3 pyramidal cells (PC) to stimulation of the dentate
gyrus (DG) are normally blocked by glutamate receptor antagonists
(GluRAs). However, after kindled seizures, GluRAs block the
monosynaptic excitatory postsynaptic potential (EPSP) and isolate a
monosynaptic inhibitory postsynaptic potential (IPSP), suggesting that
mossy fibers release GABA. However, kindling epilepsy induces neuronal
sprouting, which can underlie this fast inhibitory response. To explore
this possibility, the synaptic responses of PC to DG stimulation were
analyzed in kindled epileptic rats, with and without seizures, and in
nonepileptic rats, immediately after a single
pentylenetetrazol (PTZ)-induced seizure, in which sprouting
is unlikely to have occurred. Excitatory and inhibitory synaptic
responses of PC to DG stimulation were blocked by GluRAs in control
cells and in cells from kindled nonseizing rats, confirming that
inhibitory potentials are disynaptically mediated. However, a fast IPSP
could be evoked in kindled epileptic rats and in nonepileptic rats
after a single PTZ-induced seizure. The same response was induced after
rekindling the epileptic nonseizing rats. This IPSP has an onset
latency that parallels that of the control EPSP and is not altered
under low Ca2+ medium or halothane perfusion. In
addition, it was reversibly depressed by
L(+)-2-amino-4-phosphonobutyric acid (L-AP4),
which is known to inhibit transmitter release from mossy fibers. These results demonstrate that seizures, and not the synaptic rearrangement due to an underlying epileptic state, induce the emergence of fast
inhibition in the DG-CA3 system, and suggest that the mossy fibers
underlie this plastic change.
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