| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 85 No. 1 January 2001, pp. 10-22
Copyright ©2001 by the American Physiological Society
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019
Bastian, Joseph and
Jerry Nguyenkim.
Dendritic Modulation of Burst-Like Firing in Sensory Neurons. J. Neurophysiol. 85: 10-22, 2001. This report describes the variability of spontaneous firing
characteristics of sensory neurons, electrosensory lateral line lobe
(ELL) pyramidal cells, within the electrosensory lateral line lobe of
weakly electric fish in vivo. We show that these cells' spontaneous
firing frequency, measures of spike train regularity (interspike
interval coefficient of variation), and the tendency of these cells to
produce bursts of action potentials are correlated with the size of the
cell's apical dendritic arbor. We also show that bursting behavior may
be influenced or controlled by descending inputs from higher centers
that provide excitatory and inhibitory inputs to the pyramidal cells'
apical dendrites. Pyramidal cells were classified as "bursty" or
"nonbursty" according to whether or not spike trains deviated
significantly from the expected properties of random (Poisson) spike
trains of the same average firing frequency, and, in the case of bursty
cells, the maximum within-burst interspike interval characteristic of
bursts was determined. Each cell's probability of producing bursts
above the level expected for a Poisson spike train was determined and
related to spontaneous firing frequency and dendritic morphology.
Pyramidal cells with large apical dendritic arbors have lower rates of
spontaneous activity and higher probabilities of producing bursts above
the expected level, while cells with smaller apical dendrites fire at
higher frequencies and are less bursty. The effect of blocking non-N-methyl-D-aspartate (non-NMDA)
glutamatergic synaptic inputs to the apical dendrites of these cells,
and to local inhibitory interneurons, significantly reduced the
spontaneous occurrence of spike bursts and intracellular injection of
hyperpolarizing current mimicked this effect. The results suggest that
bursty firing of ELL pyramidal cells may be under descending control allowing activity in electrosensory feedback pathways to influence the
firing properties of sensory neurons early in the processing hierarchy.
This article has been cited by other articles:
|
|
 |
|
  R. Krahe, J. Bastian, and M. J. Chacron Temporal Processing Across Multiple Topographic Maps in the Electrosensory System J Neurophysiol, August 1, 2008; 100(2): 852 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Mehaffey, L. Maler, and R. W. Turner Intrinsic Frequency Tuning in ELL Pyramidal Cells Varies Across Electrosensory Maps J Neurophysiol, May 1, 2008; 99(5): 2641 - 2655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Chacron and J. Bastian Population Coding by Electrosensory Neurons J Neurophysiol, April 1, 2008; 99(4): 1825 - 1835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Ellis, R. Krahe, C. W. Bourque, R. J. Dunn, and M. J. Chacron Muscarinic Receptors Control Frequency Tuning Through the Downregulation of an A-Type Potassium Current J Neurophysiol, September 1, 2007; 98(3): 1526 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. M. Oswald, B. Doiron, and L. Maler Interval Coding. I. Burst Interspike Intervals as Indicators of Stimulus Intensity J Neurophysiol, April 1, 2007; 97(4): 2731 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Rennaker, C.-F. F. Chen, A. M. Ruyle, A. M. Sloan, and D. A. Wilson Spatial and Temporal Distribution of Odorant-Evoked Activity in the Piriform Cortex J. Neurosci., February 14, 2007; 27(7): 1534 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ludtke and M. E. Nelson Short-term synaptic plasticity can enhance weak signal detectability in nonrenewal spike trains. Neural Comput., December 1, 2006; 18(12): 2879 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Chacron Nonlinear Information Processing in a Model Sensory System J Neurophysiol, May 1, 2006; 95(5): 2933 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Chacron, L. Maler, and J. Bastian Feedback and Feedforward Control of Frequency Tuning to Naturalistic Stimuli J. Neurosci., June 8, 2005; 25(23): 5521 - 5532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. M. Oswald, M. J. Chacron, B. Doiron, J. Bastian, and L. Maler Parallel Processing of Sensory Input by Bursts and Isolated Spikes J. Neurosci., May 5, 2004; 24(18): 4351 - 4362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Doiron, L. Noonan, N. Lemon, and R. W. Turner Persistent Na+ Current Modifies Burst Discharge By Regulating Conditional Backpropagation of Dendritic Spikes J Neurophysiol, January 1, 2003; 89(1): 324 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kepecs, X.-J. Wang, and J. Lisman Bursting Neurons Signal Input Slope J. Neurosci., October 15, 2002; 22(20): 9053 - 9062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bastian, M. J. Chacron, and L. Maler Receptive Field Organization Determines Pyramidal Cell Stimulus-Encoding Capability and Spatial Stimulus Selectivity J. Neurosci., June 1, 2002; 22(11): 4577 - 4590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Krahe, G. Kreiman, F. Gabbiani, C. Koch, and W. Metzner Stimulus Encoding and Feature Extraction by Multiple Sensory Neurons J. Neurosci., March 15, 2002; 22(6): 2374 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Doiron, A. Longtin, R. W. Turner, and L. Maler Model of Gamma Frequency Burst Discharge Generated by Conditional Backpropagation J Neurophysiol, October 1, 2001; 86(4): 1523 - 1545. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
