JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 117-124, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (115)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kerr, J.N.D.
Right arrow Articles by Wickens, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kerr, J.N.D.
Right arrow Articles by Wickens, J. R.

The Journal of Neurophysiology Vol. 85 No. 1 January 2001, pp. 117-124
Copyright ©2001 by the American Physiological Society

Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro

J.N.D. Kerr and J. R. Wickens

Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand

Kerr, J.N.D. and J. R. Wickens. Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro. J. Neurophysiol. 85: 117-124, 2001. Dopamine and glutamate are key neurotransmitters involved in learning and memory mechanisms of the brain. These two neurotransmitter systems converge on nerve cells in the neostriatum. Dopamine modulation of activity-dependent plasticity at glutamatergic corticostriatal synapses has been proposed as a cellular mechanism for learning in the neostriatum. The present research investigated the role of specific subtypes of dopamine receptors in long-term potentiation (LTP) in the corticostriatal pathway, using intracellular recording from striatal neurons in a corticostriatal slice preparation. In agreement with previous reports, LTP could be induced reliably under Mg2+-free conditions. This Mg2+-free LTP was blocked by dopamine depletion and by the dopamine D-1/D-5 receptor antagonist SCH 23390 but was not blocked by the dopamine D-2 receptor antagonist remoxipride or the GABAA antagonist picrotoxin. In dopamine-depleted slices, the ability to induce LTP could be restored by bath application of the dopamine D-1/D-5 receptor agonist, SKF 38393. These results show that activation of dopamine D-1/D-5 receptors by either endogenous dopamine or exogenous dopamine agonists is a requirement for the induction of LTP in the corticostriatal pathway. These findings have significance for current understanding of learning and memory mechanisms of the neostriatum and for theoretical understanding of the mechanism of action of drugs used in the treatment of psychotic illnesses and Parkinson's disease.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
V. Pawlak and J. N. D. Kerr
Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity
J. Neurosci., March 5, 2008; 28(10): 2435 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y.-H. Chen, B. K. Harvey, A. F. Hoffman, Y. Wang, Y.-H. Chiang, and C. R. Lupica
MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector
FASEB J, January 1, 2008; 22(1): 261 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Wickens, J. C. Horvitz, R. M. Costa, and S. Killcross
Dopaminergic Mechanisms in Actions and Habits
J. Neurosci., August 1, 2007; 27(31): 8181 - 8183.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Kitada, A. Pisani, D. R. Porter, H. Yamaguchi, A. Tscherter, G. Martella, P. Bonsi, C. Zhang, E. N. Pothos, and J. Shen
From the Cover: Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
PNAS, July 3, 2007; 104(27): 11441 - 11446.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Adermark and D. M. Lovinger
Combined Activation of L-Type Ca2+ Channels and Synaptic Transmission Is Sufficient to Induce Striatal Long-Term Depression
J. Neurosci., June 20, 2007; 27(25): 6781 - 6787.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
J. J. Day and R. M. Carelli
The Nucleus Accumbens and Pavlovian Reward Learning
Neuroscientist, April 1, 2007; 13(2): 148 - 159.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
J. Wang, S. Carnicella, K. Phamluong, J. Jeanblanc, J. A. Ronesi, N. Chaudhri, P. H. Janak, D. M. Lovinger, and D. Ron
Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior
J. Neurosci., March 28, 2007; 27(13): 3593 - 3602.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. G. Mockett, D. Guevremont, J. M. Williams, and W. C. Abraham
Dopamine D1/D5 Receptor Activation Reverses NMDA Receptor-Dependent Long-Term Depression in Rat Hippocampus
J. Neurosci., March 14, 2007; 27(11): 2918 - 2926.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. K. Ade and D. M. Lovinger
Anandamide Regulates Postnatal Development of Long-Term Synaptic Plasticity in the Rat Dorsolateral Striatum
J. Neurosci., February 28, 2007; 27(9): 2403 - 2409.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. T. Popescu, A. A. Saghyan, and D. Pare
NMDA-dependent facilitation of corticostriatal plasticity by the amygdala
PNAS, January 2, 2007; 104(1): 341 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
M. Kudoh and K. Shibuki
Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex
Learn. Mem., November 1, 2006; 13(6): 690 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
C. Cepeda and M. S. Levine
Where Do You Think You Are Going? The NMDA-D1 Receptor Trap
Sci. Signal., May 2, 2006; 2006(333): pe20 - pe20.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. J. Hallett, R. Spoelgen, B. T. Hyman, D. G. Standaert, and A. W. Dunah
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
J. Neurosci., April 26, 2006; 26(17): 4690 - 4700.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Leblois, T. Boraud, W. Meissner, H. Bergman, and D. Hansel
Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia.
J. Neurosci., March 29, 2006; 26(13): 3567 - 3583.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Gustafson, E. Gireesh-Dharmaraj, U. Czubayko, K. T. Blackwell, and D. Plenz
A Comparative Voltage and Current-Clamp Analysis of Feedback and Feedforward Synaptic Transmission in the Striatal Microcircuit In Vitro
J Neurophysiol, February 1, 2006; 95(2): 737 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
P. J. Hernandez, M. E. Andrzejewski, K. Sadeghian, J. B. Panksepp, and A. E. Kelley
AMPA/kainate, NMDA, and dopamine D1 receptor function in the nucleus accumbens core: A context-limited role in the encoding and consolidation of instrumental memory
Learn. Mem., May 1, 2005; 12(3): 285 - 295.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
M. J. Frank
Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism
J. Cogn. Neurosci., January 1, 2005; 17(1): 51 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Ronesi and D. M. Lovinger
Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat
J. Physiol., January 1, 2005; 562(1): 245 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. N. J. Reynolds, B. I. Hyland, and J. R. Wickens
Modulation of an Afterhyperpolarization by the Substantia Nigra Induces Pauses in the Tonic Firing of Striatal Cholinergic Interneurons
J. Neurosci., November 3, 2004; 24(44): 9870 - 9877.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Centonze, A. Usiello, C. Costa, B. Picconi, E. Erbs, G. Bernardi, E. Borrelli, and P. Calabresi
Chronic Haloperidol Promotes Corticostriatal Long-Term Potentiation by Targeting Dopamine D2L Receptors
J. Neurosci., September 22, 2004; 24(38): 8214 - 8222.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Robinson, D. M. Smith, S. J. Y. Mizumori, and R. D. Palmiter
From The Cover: Firing properties of dopamine neurons in freely moving dopamine-deficient mice: Effects of dopamine receptor activation and anesthesia
PNAS, September 7, 2004; 101(36): 13329 - 13334.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. N. D. Kerr and D. Plenz
Action Potential Timing Determines Dendritic Calcium during Striatal Up-States
J. Neurosci., January 28, 2004; 24(4): 877 - 885.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Ding and D. J. Perkel
Long-Term Potentiation in an Avian Basal Ganglia Nucleus Essential for Vocal Learning
J. Neurosci., January 14, 2004; 24(2): 488 - 494.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Centonze, C. Grande, E. Saulle, A. B. Martin, P. Gubellini, N. Pavon, A. Pisani, G. Bernardi, R. Moratalla, and P. Calabresi
Distinct Roles of D1 and D5 Dopamine Receptors in Motor Activity and Striatal Synaptic Plasticity
J. Neurosci., September 17, 2003; 23(24): 8506 - 8512.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. J. Gruber, S. A. Solla, D. J. Surmeier, and J. C. Houk
Modulation of Striatal Single Units by Expected Reward: A Spiny Neuron Model Displaying Dopamine-Induced Bistability
J Neurophysiol, August 1, 2003; 90(2): 1095 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Centonze, C. Grande, A. Usiello, P. Gubellini, E. Erbs, A. B. Martin, A. Pisani, N. Tognazzi, G. Bernardi, R. Moratalla, et al.
Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons
J. Neurosci., July 16, 2003; 23(15): 6245 - 6254.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Fiorentini, F. Gardoni, P. Spano, M. Di Luca, and C. Missale
Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors
J. Biol. Chem., May 23, 2003; 278(22): 20196 - 20202.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. S. Eyny and J. C. Horvitz
Opposing Roles of D1 and D2 Receptors in Appetitive Conditioning
J. Neurosci., March 1, 2003; 23(5): 1584 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Baufreton, M. Garret, A. Rivera, A. de la Calle, F. Gonon, B. Dufy, B. Bioulac, and A. Taupignon
D5 (Not D1) Dopamine Receptors Potentiate Burst-Firing in Neurons of the Subthalamic Nucleus by Modulating an L-Type Calcium Conductance
J. Neurosci., February 1, 2003; 23(3): 816 - 825.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Gonzalez-Islas and J. J. Hablitz
Dopamine Enhances EPSCs in Layer II-III Pyramidal Neurons in Rat Prefrontal Cortex
J. Neurosci., February 1, 2003; 23(3): 867 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C. R. Calvert, E. S. Jokel, A. A. Fienberg, P. Greengard, and M. S. Levine
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
J Neurophysiol, December 1, 2002; 88(6): 3010 - 3020.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. N. D. Kerr and D. Plenz
Dendritic Calcium Encodes Striatal Neuron Output during Up-States
J. Neurosci., March 1, 2002; 22(5): 1499 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. E. Baldwin, K. Sadeghian, and A. E. Kelley
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
J. Neurosci., February 1, 2002; 22(3): 1063 - 1071.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online