JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 319-322, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Power, J. M.
Right arrow Articles by Disterhoft, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Power, J. M.
Right arrow Articles by Disterhoft, J. F.

The Journal of Neurophysiology Vol. 85 No. 1 January 2001, pp. 319-322
Copyright ©2001 by the American Physiological Society

Metrifonate Decreases sIAHP in CA1 Pyramidal Neurons In Vitro

John M. Power, M. Mathew Oh, and John F. Disterhoft

Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois 60611-3008

Power, John M., M. Mathew Oh, and John F. Disterhoft. Metrifonate Decreases sIAHP in CA1 Pyramidal Neurons In Vitro. J. Neurophysiol. 85: 319-322, 2001. Metrifonate, a cholinesterase inhibitor, has been shown to enhance learning in aging rabbits and rats, and to alleviate the cognitive deficits observed in Alzheimer's disease patients. We have previously determined that bath application of metrifonate reduces the spike frequency adaptation and postburst afterhyperpolarization (AHP) in rabbit CA1 pyramidal neurons in vitro using sharp electrode current-clamp recording. The postburst AHP and accommodation observed in current clamp are the result of four slow outward potassium currents (sIAHP, IAHP, IM, and IC) and the hyperpolarization activated mixed cation current, Ih. We recorded from visually identified CA1 hippocampal pyramidal neurons in vitro using whole cell voltage-clamp technique to better isolate and characterize which component currents of the AHP are affected by metrifonate. We observed an age-related enhancement of the slow component of the AHP tail current (sIAHP), but not of the fast decaying component of the AHP tail current (IAHP, IM, and IC). Bath perfusion of metrifonate reduced sIAHP at concentrations that cause a reduction of the AHP and accommodation in current-clamp recordings, with no apparent reduction of IAHP, IM, and IC. The functional consequences of metrifonate administration are apparently mediated solely through modulation of the sIAHP.




This article has been cited by other articles:


Home page
 AJGPHome page
G. G. Murphy, V. Shah, J. W. Hell, and A. J. Silva
Investigation of Age-Related Cognitive Decline Using Mice as a Model System: Neurophysiological Correlates
Am J Geriatr Psychiatry, December 1, 2006; 14(12): 1012 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. C. Tombaugh, W. B. Rowe, and G. M. Rose
The Slow Afterhyperpolarization in Hippocampal CA1 Neurons Covaries with Spatial Learning Ability in Aged Fisher 344 Rats
J. Neurosci., March 9, 2005; 25(10): 2609 - 2616.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
C. Weiss, E. Sametsky, A. Sasse, J. Spiess, and J. F. Disterhoft
Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons
Learn. Mem., March 1, 2005; 12(2): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. W. Wu, C. S. Chan, and J. F. Disterhoft
Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation
J Neurophysiol, October 1, 2004; 92(4): 2346 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. P. Weible, M. M. Oh, G. Lee, and J. F. Disterhoft
Galantamine Facilitates Acquisition of Hippocampus-Dependent Trace Eyeblink Conditioning in Aged Rabbits
Learn. Mem., January 1, 2004; 11(1): 108 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Power, W. W. Wu, E. Sametsky, M. M. Oh, and J. F. Disterhoft
Age-Related Enhancement of the Slow Outward Calcium-Activated Potassium Current in Hippocampal CA1 Pyramidal Neurons In Vitro
J. Neurosci., August 15, 2002; 22(16): 7234 - 7243.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online