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The Journal of Neurophysiology Vol. 85 No. 1 January 2001, pp. 391-398
Copyright ©2001 by the American Physiological Society
1Laboratory of Neurophysiology, Biomedical Research Institute, Kaunas Medical Academy, 3000 Kaunas, Lithuania; and 2Department of Medical Physiology, The Panum Institute, Copenhagen University, Copenhagen DK-2200, Denmark
Svirskis, Gytis,
Aron Gutman, and
Jørn Hounsgaard.
Electrotonic Structure of Motoneurons in the Spinal Cord of the
Turtle: Inferences for the Mechanisms of Bistability. J. Neurophysiol. 85: 391-398, 2001. Understanding how
voltage-regulated channels and synaptic membrane conductances
contribute to response properties of neurons requires reliable
knowledge of the electrotonic structure of dendritic trees. A novel
method based on weak DC field stimulation and the classical method
based on current injection were used to obtain two independent
estimates of the electrotonic structure of motoneurons in an in vitro
preparation of the turtle spinal cord. DC field stimulation was also
used to ensure that the passive membrane properties near the resting
membrane potential were homogeneous. In two cells, the difference in
electrotonic lengths estimated with the two methods in the same cell
was 6 and 9%. The majority of dendritic branches terminated at a
distance of 1 electrotonic unit from the recording site. The longest
branches reached 2
. In the third cell, the difference was
36%, demonstrating the need to use both methods, field stimulation and
current injection, for reliable measurements of the electrotonical
structure. Models of the reconstructed cells endowed with
voltage-dependent conductances were used to explore generation
mechanisms for the experimentally observed hysteresis in input
current-voltage relation of bistable motoneurons. The results of
modeling suggest that only some dendrites need to possess L-type
calcium current to explain the hysteresis observed experimentally and
that dendritic branches with different electrotonical lengths can be
bistable. Independent bistable behavior in individual dendritic
branches can make motoneurons complex processing units.
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