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The Journal of Neurophysiology Vol. 85 No. 2 February 2001, pp. 828-842
Copyright ©2001 by the American Physiological Society
Section of Neurobiology, University of Texas, Austin, Texas 78712
Hurley, Laura M. and
George D. Pollak.
Serotonin Effects on Frequency Tuning of Inferior
Colliculus Neurons. J. Neurophysiol. 85: 828-842, 2001. We investigated the modulatory effects of serotonin on the
tuning of 114 neurons in the central nucleus of the inferior colliculus (ICc) of Mexican free-tailed bats and how serotonin-induced changes in
tuning influenced responses to complex signals. We obtained a
"response area" for each neuron, defined as the frequency range that evoked discharges and the spike counts evoked by those frequencies at a constant intensity. We then iontophoretically applied serotonin and compared response areas obtained before and during the application of serotonin. In 58 cells, we also assessed how serotonin-induced changes in response areas correlated with changes in the responses to
brief frequency-modulated (FM) sweeps whose structure simulated natural
echolocation calls. Serotonin profoundly changed tone-evoked spike
counts in 60% of the neurons (68/114). In most neurons, serotonin
exerted a gain control, facilitating or depressing the responses to all
frequencies in their response areas. In many cells, serotonergic
effects on tones were reflected in the responses to FM signals. The
most interesting effects were in those cells in which serotonin
selectively changed the responsiveness to only some frequencies in the
neuron's response area and had little or no effect on other
frequencies. This caused predictable changes in responses to the more
complex FM sweeps whose spectral components passed through the
neurons' response areas. Our results suggest that serotonin, whose
release varies with behavioral state, functionally reconfigures the
circuitry of the IC and may modulate the perception of acoustic signals
under different behavioral states.
This article has been cited by other articles:
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  L. M. Hurley, J. A. Tracy, and A. Bohorquez Serotonin 1B Receptor Modulates Frequency Response Curves and Spectral Integration in the Inferior Colliculus by Reducing GABAergic Inhibition J Neurophysiol, September 1, 2008; 100(3): 1656 - 1667. [Abstract] [Full Text] [PDF]
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 R. Xie, J. X. Gittelman, and G. D. Pollak Rethinking Tuning: In Vivo Whole-Cell Recordings of the Inferior Colliculus in Awake Bats J. Neurosci., August 29, 2007; 27(35): 9469 - 9481. [Abstract] [Full Text] [PDF]
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L. M. Hurley Different Serotonin Receptor Agonists Have Distinct Effects on Sound-Evoked Responses in Inferior Colliculus J Neurophysiol, November 1, 2006; 96(5): 2177 - 2188. [Abstract] [Full Text] [PDF]
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R. R. Metzger, N. T. Greene, K. K. Porter, and J. M. Groh Effects of reward and behavioral context on neural activity in the primate inferior colliculus. J. Neurosci., July 12, 2006; 26(28): 7468 - 7476. [Abstract] [Full Text] [PDF]
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R. Xie, J. Meitzen, and G. D. Pollak Differing Roles of Inhibition in Hierarchical Processing of Species-Specific Calls in Auditory Brainstem Nuclei J Neurophysiol, December 1, 2005; 94(6): 4019 - 4037. [Abstract] [Full Text] [PDF]
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L. M. Hurley and G. D. Pollak Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons J. Neurosci., August 24, 2005; 25(34): 7876 - 7886. [Abstract] [Full Text] [PDF]
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U. Koch and B. Grothe Hyperpolarization-Activated Current (Ih) in the Inferior Colliculus: Distribution and Contribution to Temporal Processing J Neurophysiol, December 1, 2003; 90(6): 3679 - 3687. [Abstract] [Full Text] [PDF]
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