| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 85 No. 2 February 2001, pp. 926-937
Copyright ©2001 by the American Physiological Society
1Department of Physiology, University College London, London WC1E 6BT, United Kingdom; and 2Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, D-69120 Heidelberg, Germany
Vetter, Philipp,
Arnd Roth, and
Michael Häusser.
Propagation of Action Potentials in Dendrites Depends on
Dendritic Morphology. J. Neurophysiol. 85: 926-937, 2001. Action potential propagation links information
processing in different regions of the dendritic tree. To examine the
contribution of dendritic morphology to the efficacy of propagation,
simulations were performed in detailed reconstructions of eight
different neuronal types. With identical complements of voltage-gated
channels, different dendritic morphologies exhibit distinct patterns of propagation. Remarkably, the range of backpropagation efficacies observed experimentally can be reproduced by the variations in dendritic morphology alone. Dendritic geometry also determines the
extent to which modulation of channel densities can affect propagation.
Thus in Purkinje cells and dopamine neurons, backpropagation is
relatively insensitive to changes in channel densities, whereas in
pyramidal cells, backpropagation can be modulated over a wide range. We
also demonstrate that forward propagation of dendritically initiated
action potentials is influenced by morphology in a similar manner. We
show that these functional consequences of the differences in dendritic
geometries can be explained quantitatively using simple anatomical
measures of dendritic branching patterns, which are captured in a
reduced model of dendritic geometry. These findings indicate that
differences in dendritic geometry act in concert with differences in
voltage-gated channel density and kinetics to generate the diversity in
dendritic action potential propagation observed between neurons. They
also suggest that changes in dendritic geometry during development and
plasticity will critically affect propagation. By determining the
spatial pattern of action potential signaling, dendritic morphology
thus helps to define the size and interdependence of functional
compartments in the neuron.
This article has been cited by other articles:
|
|
 |
|
  D. Carrel, Y. Du, D. Komlos, N. M. Hadzimichalis, M. Kwon, B. Wang, L. M. Brzustowicz, and B. L. Firestein NOS1AP Regulates Dendrite Patterning of Hippocampal Neurons through a Carboxypeptidase E-Mediated Pathway J. Neurosci., June 24, 2009; 29(25): 8248 - 8258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gidon and I. Segev Spike-Timing-Dependent Synaptic Plasticity and Synaptic Democracy in Dendrites J Neurophysiol, June 1, 2009; 101(6): 3226 - 3234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Acker and S. D. Antic Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites J Neurophysiol, March 1, 2009; 101(3): 1524 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Day, D. Wokosin, J. L. Plotkin, X. Tian, and D. J. Surmeier Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites J. Neurosci., November 5, 2008; 28(45): 11603 - 11614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Gertler, C. S. Chan, and D. J. Surmeier Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons J. Neurosci., October 22, 2008; 28(43): 10814 - 10824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Davie, B. A. Clark, and M. Hausser The Origin of the Complex Spike in Cerebellar Purkinje Cells J. Neurosci., July 23, 2008; 28(30): 7599 - 7609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Cho, H.-J. Jang, E.-H. Lee, S. H. Yoon, S. J. Hahn, Y.-H. Jo, M.-S. Kim, and D.-J. Rhie Differential Cholinergic Modulation of Ca2+ Transients Evoked by Backpropagating Action Potentials in Apical and Basal Dendrites of Cortical Pyramidal Neurons J Neurophysiol, June 1, 2008; 99(6): 2833 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wen and D. B. Chklovskii A Cost-Benefit Analysis of Neuronal Morphology J Neurophysiol, May 1, 2008; 99(5): 2320 - 2328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Larkum, S. Watanabe, N. Lasser-Ross, P. Rhodes, and W. N. Ross Dendritic Properties of Turtle Pyramidal Neurons J Neurophysiol, February 1, 2008; 99(2): 683 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Angelo, M. London, S. R. Christensen, and M. Hausser Local and Global Effects of Ih Distribution in Dendrites of Mammalian Neurons J. Neurosci., August 8, 2007; 27(32): 8643 - 8653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Bekkers and M. Hausser Targeted dendrotomy reveals active and passive contributions of the dendritic tree to synaptic integration and neuronal output PNAS, July 3, 2007; 104(27): 11447 - 11452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Stiefel and T. J. Sejnowski Mapping Function Onto Neuronal Morphology J Neurophysiol, July 1, 2007; 98(1): 513 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Fernandez, J. D. T. Engbers, and R. W. Turner Firing Dynamics of Cerebellar Purkinje Cells J Neurophysiol, July 1, 2007; 98(1): 278 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Blythe, J. F. Atherton, and M. D. Bevan Synaptic Activation of Dendritic AMPA and NMDA Receptors Generates Transient High-Frequency Firing in Substantia Nigra Dopamine Neurons In Vitro J Neurophysiol, April 1, 2007; 97(4): 2837 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Schaefer, M. Helmstaedter, A. C. Schmitt, D. Bar-Yehuda, M. Almog, H. Ben-Porat, B. Sakmann, and A. Korngreen Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of neocortical layer 5B from rats J. Physiol., March 15, 2007; 579(3): 737 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Bullis, T. D. Jones, and N. P. Poolos Reversed somatodendritic Ih gradient in a class of rat hippocampal neurons with pyramidal morphology J. Physiol., March 1, 2007; 579(2): 431 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Gentet and S. R. Williams Dopamine Gates Action Potential Backpropagation in Midbrain Dopaminergic Neurons J. Neurosci., February 21, 2007; 27(8): 1892 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Charych, B. F. Akum, J. S. Goldberg, R. J. Jornsten, C. Rongo, J. Q. Zheng, and B. L. Firestein Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95 J. Neurosci., October 4, 2006; 26(40): 10164 - 10176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Yang, A. Z. Harris, and D. L. Pettit Variable Kainate Receptor Distributions of Oriens Interneurons J Neurophysiol, September 1, 2006; 96(3): 1683 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Gao, G. Chen, K. C. Reinert, and T. J. Ebner Cerebellar cortical molecular layer inhibition is organized in parasagittal zones. J. Neurosci., August 9, 2006; 26(32): 8377 - 8387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. J. M. Huys, M. B. Ahrens, and L. Paninski Efficient Estimation of Detailed Single-Neuron Models J Neurophysiol, August 1, 2006; 96(2): 872 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Krichmar, D. Velasquez, and G. A. Ascoli Effects of {beta}-Catenin on Dendritic Morphology and Simulated Firing Patterns in Cultured Hippocampal Neurons. Biol. Bull., August 1, 2006; 211(1): 31 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Kampa and G. J. Stuart Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. J. Neurosci., July 12, 2006; 26(28): 7424 - 7432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. de Ruiter, C. I. De Zeeuw, and C. Hansel Voltage-Gated Sodium Channels in Cerebellar Purkinje Cells of Mormyrid Fish J Neurophysiol, July 1, 2006; 96(1): 378 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Iyer, T. M. Hoogland, and P. Saggau Fast Functional Imaging of Single Neurons Using Random-Access Multiphoton (RAMP) Microscopy J Neurophysiol, January 1, 2006; 95(1): 535 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Migliore, M. Ferrante, and G. A. Ascoli Signal Propagation in Oblique Dendrites of CA1 Pyramidal Cells J Neurophysiol, December 1, 2005; 94(6): 4145 - 4155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chen, K. G. Lucas, B. F. Akum, G. Balasingam, T. M. Stawicki, J. M. Provost, G. M. Riefler, R. J. Jornsten, and B. L. Firestein A Novel Role for Snapin in Dendrite Patterning: Interaction with Cypin Mol. Biol. Cell, November 1, 2005; 16(11): 5103 - 5114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E McKay and R. W Turner Physiological and morphological development of the rat cerebellar Purkinje cell J. Physiol., September 15, 2005; 567(3): 829 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Hossain, S. D. Antic, Y. Yang, M. N. Rasband, and D. K. Morest Where Is the Spike Generator of the Cochlear Nerve? Voltage-Gated Sodium Channels in the Mouse Cochlea J. Neurosci., July 20, 2005; 25(29): 6857 - 6868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Evers, S. Schmitt, M. Sibila, and C. Duch Progress in Functional Neuroanatomy: Precise Automatic Geometric Reconstruction of Neuronal Morphology From Confocal Image Stacks J Neurophysiol, April 1, 2005; 93(4): 2331 - 2342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Canals, L. Lopez-Aguado, and O. Herreras Synaptically Recruited Apical Currents Are Required to Initiate Axonal and Apical Spikes in Hippocampal Pyramidal Cells: Modulation by Inhibition J Neurophysiol, February 1, 2005; 93(2): 909 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Doi, S. Kuroda, T. Michikawa, and M. Kawato Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Threshold Dynamics Detect Spike Timing in Cerebellar Purkinje Cells J. Neurosci., January 26, 2005; 25(4): 950 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Roth and M. London Rebuilding Dendritic Democracy. Focus on "Equalization of Synaptic Efficacy by Activity- and Timing-Dependent Synaptic Plasticity" J Neurophysiol, May 1, 2004; 91(5): 1941 - 1942. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Hanson, Y. Smith, and D. Jaeger Sodium Channels and Dendritic Spike Initiation at Excitatory Synapses in Globus Pallidus Neurons J. Neurosci., January 14, 2004; 24(2): 329 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Gulledge and G. J. Stuart Action Potential Initiation and Propagation in Layer 5 Pyramidal Neurons of the Rat Prefrontal Cortex: Absence of Dopamine Modulation J. Neurosci., December 10, 2003; 23(36): 11363 - 11372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Saraga, C P Wu, L Zhang, and F K Skinner Active dendrites and spike propagation in multicompartment models of oriens-lacunosum/moleculare hippocampal interneurons J. Physiol., November 1, 2003; 552(3): 673 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mellon Jr. Dendritic Initiation and Propagation of Spikes and Spike Bursts in a Multimodal Sensory Interneuron: The Crustacean Parasol Cell J Neurophysiol, October 1, 2003; 90(4): 2465 - 2477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Waters, M. Larkum, B. Sakmann, and F. Helmchen Supralinear Ca2+ Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo J. Neurosci., September 17, 2003; 23(24): 8558 - 8567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bernard and D. Johnston Distance-Dependent Modifiable Threshold for Action Potential Back-Propagation in Hippocampal Dendrites J Neurophysiol, September 1, 2003; 90(3): 1807 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Egger, K. Svoboda, and Z. F. Mainen Mechanisms of Lateral Inhibition in the Olfactory Bulb: Efficiency and Modulation of Spike-Evoked Calcium Influx into Granule Cells J. Neurosci., August 20, 2003; 23(20): 7551 - 7558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H Goldberg, G. Tamas, and R. Yuste Ca2+ imaging of mouse neocortical interneurone dendrites: Ia-type K+ channels control action potential backpropagation J. Physiol., August 15, 2003; 551(1): 49 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Martina, G. L. Yao, and B. P. Bean Properties and Functional Role of Voltage-Dependent Potassium Channels in Dendrites of Rat Cerebellar Purkinje Neurons J. Neurosci., July 2, 2003; 23(13): 5698 - 5707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D Antic Action potentials in basal and oblique dendrites of rat neocortical pyramidal neurons J. Physiol., July 1, 2003; 550(1): 35 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Spruston Branching Out: A New Idea for Dendritic Function. Focus on "Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern" J Neurophysiol, June 1, 2003; 89(6): 2887 - 2888. [Full Text] [PDF]
|
|
|
|
|
|
A. T. Schaefer, M. E. Larkum, B. Sakmann, and A. Roth Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern J Neurophysiol, June 1, 2003; 89(6): 3143 - 3154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rudolph and A. Destexhe A Fast-Conducting, Stochastic Integrative Mode for Neocortical Neurons InVivo J. Neurosci., March 15, 2003; 23(6): 2466 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lopez-Aguado, J. M. Ibarz, P. Varona, and O. Herreras Structural Inhomogeneities Differentially Modulate Action Currents and Population Spikes Initiated in the Axon or Dendrites J Neurophysiol, November 1, 2002; 88(5): 2809 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tsay and R. Yuste Role of Dendritic Spines in Action Potential Backpropagation: A Numerical Simulation Study J Neurophysiol, November 1, 2002; 88(5): 2834 - 2845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Inglis, R. Crockett, S. Korada, W. C. Abraham, M. Hollmann, and R. G. Kalb The AMPA Receptor Subunit GluR1 Regulates Dendritic Architecture of Motor Neurons J. Neurosci., September 15, 2002; 22(18): 8042 - 8051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gasparini and J. C Magee Phosphorylation-dependent differences in the activation properties of distal and proximal dendritic Na+ channels in rat CA1 hippocampal neurons J. Physiol., June 15, 2002; 541(3): 665 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. D. Kerr and D. Plenz Dendritic Calcium Encodes Striatal Neuron Output during Up-States J. Neurosci., March 1, 2002; 22(5): 1499 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Golding, W. L. Kath, and N. Spruston Dichotomy of Action-Potential Backpropagation in CA1 Pyramidal Neuron Dendrites J Neurophysiol, December 1, 2001; 86(6): 2998 - 3010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Roth and M. Hausser Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings J. Physiol., September 1, 2001; 535(2): 445 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M E Larkum, J J Zhu, and B Sakmann Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons J. Physiol., June 1, 2001; 533(2): 447 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston, R. Benavides-Piccione, and J. DeFelipe The Pyramidal Cell in Cognition: A Comparative Study in Human and Monkey J. Neurosci., September 1, 2001; 21(17): RC163 - RC163. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
