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The Journal of Neurophysiology Vol. 85 No. 2 February 2001, pp. 960-976
Copyright ©2001 by the American Physiological Society
1Faculty of Health and Sport Sciences, Osaka University, Osaka 560-0043, Japan; 2Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139; and 3Department of Physiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Matsumoto, Naoyuki,
Takafumi Minamimoto,
Ann M. Graybiel, and
Minoru Kimura.
Neurons in the Thalamic CM-Pf Complex Supply Striatal Neurons
With Information About Behaviorally Significant Sensory Events. J. Neurophysiol. 85: 960-976, 2001. The projection from the thalamic centre
médian-parafascicular (CM-Pf) complex to the caudate nucleus and
putamen forms a massive striatal input system in primates. We examined
the activity of 118 neurons in the CM and 62 neurons in the Pf nuclei
of the thalamus and 310 tonically active neurons (TANs) in the striatum in awake behaving macaque monkeys and analyzed the effects of pharmacologic inactivation of the CM-Pf on the sensory responsiveness of the striatal TANs. A large proportion of CM and Pf neurons responded
to visual (53%) and/or auditory beep (61%) or click (91%) stimuli
presented in behavioral tasks, and many responded to unexpected
auditory, visual, or somatosensory stimuli presented outside the task
context. The neurons fell into two classes: those having short-latency
facilitatory responses (SLF neurons, predominantly in the Pf) and those
having long-latency facilitatory responses (LLF neurons, predominantly
in the CM). Responses of both types of neuron appeared regardless of
whether or not the sensory stimuli were associated with reward. These
response characteristics of CM-Pf neurons sharply contrasted with those
of TANs in the striatum, which under the same conditions responded
preferentially to stimuli associated with reward. Many CM-Pf neurons
responded to alerting stimuli such as unexpected handclaps and noises
only for the first few times that they occurred; after that, the
identical stimuli gradually became ineffective in evoking responses.
Habituation of sensory responses was particularly common for the LLF
neurons. Inactivation of neuronal activity in the CM and Pf by local
infusion of the GABAA receptor agonist, muscimol,
almost completely abolished the pause and rebound facilitatory
responses of TANs in the striatum. Such injections also diminished
behavioral responses to stimuli associated with reward. We suggest that
neurons in the CM and Pf supply striatal neurons with information about
behaviorally significant sensory events that can activate conditional
responses of striatal neurons in combination with dopamine-mediated
nigrostriatal inputs having motivational value.
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