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J Neurophysiol 85: 1051-1058, 2001;
0022-3077/01 $5.00
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The Journal of Neurophysiology Vol. 85 No. 3 March 2001, pp. 1051-1058
Copyright ©2001 by the American Physiological Society

Modulation by Extracellular pH of Low- and High-Voltage-Activated Calcium Currents of Rat Thalamic Relay Neurons

Mukesch Johannes Shah, Susanne Meis, Thomas Munsch, and Hans-Christian Pape

Institut für Physiologie, Medizinische Fakultät, Otto-von-Guericke Universität, D-39120 Magdeburg, Germany

Shah, Mukesch Johannes, Susanne Meis, Thomas Munsch, and Hans-Christian Pape. Modulation by Extracellular pH of Low- and High-Voltage-Activated Calcium Currents of Rat Thalamic Relay Neurons. J. Neurophysiol. 85: 1051-1058, 2001. The effects of changes in the extracellular pH (pHo) on low-voltage- (LVA) and high-voltage- (HVA) activated calcium currents of acutely isolated relay neurons of the ventrobasal thalamic complex (VB) were examined using the whole cell patch-clamp technique. Modest extracellular alkalinization (pH 7.3 to 7.7) reversibly enlarged LVA calcium currents by 18.6 ± 3.2% (mean ± SE, n = 6), whereas extracellular acidification (pH 7.3 to 6.9) decreased the current by 24.8 ± 3.1% (n = 9). Normalized current amplitudes (I/I7.3) fitted as a function of pHo revealed an apparent pKa of 6.9. Both, half-maximal activation voltage and steady-state inactivation were significantly shifted to more negative voltages by 2-4 mV on extracellular alkalinization and to more positive voltages by 2-3 mV on extracellular acidification, respectively. Recovery from inactivation of LVA calcium currents was not significantly affected by changes in pHo. In contrast, HVA calcium currents were less sensitive to changes in pHo. Although extracellular alkalinization increased maximal HVA current by 6.0 ± 2.0% (n = 7) and extracellular acidification decreased it by 11.9 ± 0.02% (n = 11), both activation and steady-state inactivation were only marginally affected by the moderate changes in pHo used in the present study. The results show that calcium currents of thalamic relay neurons exhibit different pHo sensitivity. Therefore activity-related extracellular pH transients might selectively modulate certain aspects of the electrogenic behavior of thalamic relay neurons.




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