JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 1051-1058, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shah, M. J.
Right arrow Articles by Pape, H.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shah, M. J.
Right arrow Articles by Pape, H.-C.

The Journal of Neurophysiology Vol. 85 No. 3 March 2001, pp. 1051-1058
Copyright ©2001 by the American Physiological Society

Modulation by Extracellular pH of Low- and High-Voltage-Activated Calcium Currents of Rat Thalamic Relay Neurons

Mukesch Johannes Shah, Susanne Meis, Thomas Munsch, and Hans-Christian Pape

Institut für Physiologie, Medizinische Fakultät, Otto-von-Guericke Universität, D-39120 Magdeburg, Germany

Shah, Mukesch Johannes, Susanne Meis, Thomas Munsch, and Hans-Christian Pape. Modulation by Extracellular pH of Low- and High-Voltage-Activated Calcium Currents of Rat Thalamic Relay Neurons. J. Neurophysiol. 85: 1051-1058, 2001. The effects of changes in the extracellular pH (pHo) on low-voltage- (LVA) and high-voltage- (HVA) activated calcium currents of acutely isolated relay neurons of the ventrobasal thalamic complex (VB) were examined using the whole cell patch-clamp technique. Modest extracellular alkalinization (pH 7.3 to 7.7) reversibly enlarged LVA calcium currents by 18.6 ± 3.2% (mean ± SE, n = 6), whereas extracellular acidification (pH 7.3 to 6.9) decreased the current by 24.8 ± 3.1% (n = 9). Normalized current amplitudes (I/I7.3) fitted as a function of pHo revealed an apparent pKa of 6.9. Both, half-maximal activation voltage and steady-state inactivation were significantly shifted to more negative voltages by 2-4 mV on extracellular alkalinization and to more positive voltages by 2-3 mV on extracellular acidification, respectively. Recovery from inactivation of LVA calcium currents was not significantly affected by changes in pHo. In contrast, HVA calcium currents were less sensitive to changes in pHo. Although extracellular alkalinization increased maximal HVA current by 6.0 ± 2.0% (n = 7) and extracellular acidification decreased it by 11.9 ± 0.02% (n = 11), both activation and steady-state inactivation were only marginally affected by the moderate changes in pHo used in the present study. The results show that calcium currents of thalamic relay neurons exhibit different pHo sensitivity. Therefore activity-related extracellular pH transients might selectively modulate certain aspects of the electrogenic behavior of thalamic relay neurons.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
V. Crunelli, T. I. Toth, D. W. Cope, K. Blethyn, and S. W. Hughes
The 'window' T-type calcium current in brain dynamics of different behavioural states
J. Physiol., January 1, 2005; 562(1): 121 - 129.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Putnam, J. A. Filosa, and N. A. Ritucci
Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1493 - C1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Zhang, A. P. Vilaythong, D. Yoshor, and J. L. Noebels
Elevated Thalamic Low-Voltage-Activated Currents Precede the Onset of Absence Epilepsy in the SNAP25-Deficient Mouse Mutant Coloboma
J. Neurosci., June 2, 2004; 24(22): 5239 - 5248.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
K. Talavera, A. Janssens, N. Klugbauer, G. Droogmans, and B. Nilius
Extracellular Ca2+ Modulates the Effects of Protons on Gating and Conduction Properties of the T-type Ca2+ Channel {alpha}1G (CaV3.1)
J. Gen. Physiol., May 27, 2003; 121(6): 511 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Perez-Reyes
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Physiol Rev, January 1, 2003; 83(1): 117 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. A. Filosa and R. W. Putnam
Multiple targets of chemosensitive signaling in locus coeruleus neurons: role of K+ and Ca2+ channels
Am J Physiol Cell Physiol, January 1, 2003; 284(1): C145 - C155.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Zhang, M. Mori, D. L. Burgess, and J. L. Noebels
Mutations in High-Voltage-Activated Calcium Channel Genes Stimulate Low-Voltage-Activated Currents in Mouse Thalamic Relay Neurons
J. Neurosci., August 1, 2002; 22(15): 6362 - 6371.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. J. Perry, V. A. Straub, M. G. Schofield, J. F. Burke, and P. R. Benjamin
Neuronal Expression of an FMRFamide-Gated Na+ Channel and Its Modulation by Acid pH
J. Neurosci., August 1, 2001; 21(15): 5559 - 5567.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online