JN Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 1275-1282, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salin, P.-A.
Right arrow Articles by Charpak, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salin, P.-A.
Right arrow Articles by Charpak, S.

The Journal of Neurophysiology Vol. 85 No. 3 March 2001, pp. 1275-1282
Copyright ©2001 by the American Physiological Society

Dendritic Glutamate Autoreceptors Modulate Signal Processing in Rat Mitral Cells

Paul-Antoine Salin,1,2,3 Pierre-Marie Lledo,3 Jean-Didier Vincent,3 and Serge Charpak1

 1Laboratory of Physiology, Ecole Supérieure de Physique et Chimie, 75005 Paris;  2Centres des Sciences du Goût-Centre National de la Recherche Scientifique, 21000 Dijon; and  3Centre National de la Recherche Scientifique, Institut Alfred Fessard, 91198 Gif sur Yvette, France

Salin, Paul-Antoine, Pierre-Marie Lledo, Jean-Didier Vincent, and Serge Charpak. Dendritic Glutamate Autoreceptors Modulate Signal Processing in Rat Mitral Cells. J. Neurophysiol. 85: 1275-1282, 2001. It has been shown recently that in mitral cells of the rat olfactory bulb, N-methyl-D-aspartate (NMDA) autoreceptors are activated during mitral cell firing. Here we consider in more details the mechanisms of mitral cell self-excitation and its physiological relevance. We show that both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid (BAPTA) and result from a calcium-dependent release of glutamate. Self-excitation can be produced by a single spike, and trains of spikes result in frequency facilitation. Thus activation of excitatory autoreceptors is a major function of action potentials backpropagating in mitral cell dendrites, which results in an immediate positive feedback counteracting recurrent inhibition and increasing the signal-to-noise ratio of olfactory inputs.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
Y. S. Kim, J. H. Shin, F. S. Hall, and D. J. Linden
Dopamine Signaling Is Required for Depolarization-Induced Slow Current in Cerebellar Purkinje Cells
J. Neurosci., July 1, 2009; 29(26): 8530 - 8538.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. De Saint Jan, D. Hirnet, G. L. Westbrook, and S. Charpak
External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli
J. Neurosci., February 18, 2009; 29(7): 2043 - 2052.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. Wilson and C. Linster
Neurobiology of a Simple Memory
J Neurophysiol, July 1, 2008; 100(1): 2 - 7.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. O. Pimentel and T. W. Margrie
Glutamatergic transmission and plasticity between olfactory bulb mitral cells
J. Physiol., April 15, 2008; 586(8): 2107 - 2119.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. M. McNamara, P. D. Magidson, C. Linster, D. A. Wilson, and T. A. Cleland
Distinct neural mechanisms mediate olfactory memory formation at different timescales
Learn. Mem., February 22, 2008; 15(3): 117 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. H. Shin, Y. S. Kim, and D. J. Linden
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells
PNAS, January 15, 2008; 105(2): 746 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. De Saint Jan and G. L. Westbrook
Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb
J. Neurosci., January 3, 2007; 27(1): 132 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Laaris, A. Puche, and M. Ennis
Complementary Postsynaptic Activity Patterns Elicited in Olfactory Bulb by Stimulation of Mitral/Tufted and Centrifugal Fiber Inputs to Granule Cells
J Neurophysiol, January 1, 2007; 97(1): 296 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Heinbockel, N. Laaris, and M. Ennis
Metabotropic Glutamate Receptors in the Main Olfactory Bulb Drive Granule Cell-Mediated Inhibition
J Neurophysiol, January 1, 2007; 97(1): 858 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. B. Rubin and T. A. Cleland
Dynamical Mechanisms of Odor Processing in Olfactory Bulb Mitral Cells
J Neurophysiol, August 1, 2006; 96(2): 555 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Q. Yuan and T. Knopfel
Olfactory Nerve Stimulation-Induced Calcium Signaling in the Mitral Cell Distal Dendritic Tuft
J Neurophysiol, April 1, 2006; 95(4): 2417 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Ennis, M. Zhu, T. Heinbockel, and A. Hayar
Olfactory Nerve-Evoked, Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Rat Olfactory Bulb Mitral Cells
J Neurophysiol, April 1, 2006; 95(4): 2233 - 2241.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Christie and G. L. Westbrook
Lateral excitation within the olfactory bulb.
J. Neurosci., February 22, 2006; 26(8): 2269 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. Zochowski and L. B. Cohen
Oscillations in the Olfactory Bulb Carry Information About Odorant History
J Neurophysiol, October 1, 2005; 94(4): 2667 - 2675.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Carson, M. Saleh, F. W. Fung, D. W. Nicholson, and A. J. Roskams
Axonal Dynactin p150Glued Transports Caspase-8 to Drive Retrograde Olfactory Receptor Neuron Apoptosis
J. Neurosci., June 29, 2005; 25(26): 6092 - 6104.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. N. Urban and J. B. Castro
Tuft Calcium Spikes in Accessory Olfactory Bulb Mitral Cells
J. Neurosci., May 18, 2005; 25(20): 5024 - 5028.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P.-M. Lledo, G. Gheusi, and J.-D. Vincent
Information Processing in the Mammalian Olfactory System
Physiol Rev, January 1, 2005; 85(1): 281 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Heinbockel, P. Heyward, F. Conquet, and M. Ennis
Regulation of Main Olfactory Bulb Mitral Cell Excitability by Metabotropic Glutamate Receptor mGluR1
J Neurophysiol, November 1, 2004; 92(5): 3085 - 3096.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Hayar, S. Karnup, M. Ennis, and M. T. Shipley
External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity
J. Neurosci., July 28, 2004; 24(30): 6676 - 6685.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Hayar, S. Karnup, M. T. Shipley, and M. Ennis
Olfactory Bulb Glomeruli: External Tufted Cells Intrinsically Burst at Theta Frequency and Are Entrained by Patterned Olfactory Input
J. Neurosci., February 4, 2004; 24(5): 1190 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Lowe
Flash Photolysis Reveals a Diversity of Ionotropic Glutamate Receptors on the Mitral Cell Somatodendritic Membrane
J Neurophysiol, September 1, 2003; 90(3): 1737 - 1746.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Debarbieux, E. Audinat, and S. Charpak
Action Potential Propagation in Dendrites of Rat Mitral Cells In Vivo
J. Neurosci., July 2, 2003; 23(13): 5553 - 5560.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. S. Isaacson and H. Vitten
GABAB Receptors Inhibit Dendrodendritic Transmission in the Rat Olfactory Bulb
J. Neurosci., March 15, 2003; 23(6): 2032 - 2039.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. N Urban and B. Sakmann
Reciprocal intraglomerular excitation and intra- and interglomerular lateral inhibition between mouse olfactory bulb mitral cells
J. Physiol., July 15, 2002; 542(2): 355 - 367.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Lowe
Inhibition of Backpropagating Action Potentials in Mitral Cell Secondary Dendrites
J Neurophysiol, July 1, 2002; 88(1): 64 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Didier, A. Carleton, J. G. Bjaalie, J.-D. Vincent, O. P. Ottersen, J. Storm-Mathisen, and P.-M. Lledo
A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb
PNAS, May 22, 2001; 98(11): 6441 - 6446.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online