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The Journal of Neurophysiology Vol. 85 No. 3 March 2001, pp. 1283-1298
Copyright ©2001 by the American Physiological Society
Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, The University of Queensland, St. Lucia, Queensland 4072, Australia
Spitzer, Matthew W.,
Michael B. Calford,
Janine C. Clarey,
John D. Pettigrew, and
Anna
W. Roe.
Spontaneous and Stimulus-Evoked Intrinsic Optical Signals in
Primary Auditory Cortex of the Cat. J. Neurophysiol. 85: 1283-1298, 2001. Spontaneous and tone-evoked changes
in light reflectance were recorded from primary auditory cortex (A1) of
anesthetized cats (barbiturate induction, ketamine maintenance).
Spontaneous 0.1-Hz oscillations of reflectance of 540- and 690-nm light
were recorded in quiet. Stimulation with tone pips evoked localized
reflectance decreases at 540 nm in 3/10 cats. The distribution of
patches "activated" by tones of different frequencies reflected the
known tonotopic organization of auditory cortex. Stimulus-evoked
reflectance changes at 690 nm were observed in 9/10 cats but lacked
stimulus-dependent topography. In two experiments, stimulus-evoked
optical signals at 540 nm were compared with multiunit responses to the
same stimuli recorded at multiple sites. A significant correlation
(P < 0.05) between magnitude of reflectance decrease
and multiunit response strength was evident in only one of five
stimulus conditions in each experiment. There was no significant
correlation when data were pooled across all stimulus conditions in
either experiment. In one experiment, the spatial distribution of
activated patches, evident in records of spontaneous activity at 540 nm, was similar to that of patches activated by tonal stimuli. These
results suggest that local cerebral blood volume changes reflect the
gross tonotopic organization of A1 but are not restricted to the sites
of spiking neurons.
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