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J Neurophysiol 85: 1336-1339, 2001;
0022-3077/01 $5.00
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The Journal of Neurophysiology Vol. 85 No. 3 March 2001, pp. 1336-1339
Copyright ©2001 by the American Physiological Society

RAPID COMMUNICATION

Dopaminergic Substantia Nigra Neurons Express Functional NMDA Receptors in Postnatal Rats

John Yu-Luen Lin and Janusz Lipski

Department of Physiology, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand

Lin, John Yu-Luen and Janusz Lipski. Dopaminergic Substantia Nigra Neurons Express Functional NMDA Receptors in Postnatal Rats. J. Neurophysiol. 85: 1336-1339, 2001. Activation of N-methyl-D-aspartate (NMDA) receptors in the Substantia Nigra zona compacta (SNc) may determine the degree of physiological apoptosis during the early postnatal period. However, the expression of these receptors during this stage of development is uncertain, as a recent study failed to detect responses to NMDA in unidentified SNc neurons isolated from 2-wk-old rats. Using conventional or perforated-patch whole cell recordings, we examined the presence of NMDA-evoked responses in SNc neurons acutely dissociated from P4 to P16 rats, applying strict criteria for identification of these neurons as nigrostriatal and dopaminergic. The SNc neurons were identified by retrograde labeling after striatal injection of Fluoro-Gold; the presence of Ih current; and the inhibition of firing by dopamine (50 µM). NMDA (100 µM, Vhold = -60 mV) evoked inward, APV-sensitive currents (56.4 ± 8.6 pA) in all tested neurons (n = 29). Strong depolarizing responses were observed under current-clamp. These results indicate that NMDA receptors play a functional role in SNc neurons during the first two postnatal weeks.




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