JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 1498-1501, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schnell, E.
Right arrow Articles by Nicoll, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schnell, E.
Right arrow Articles by Nicoll, R. A.

The Journal of Neurophysiology Vol. 85 No. 4 April 2001, pp. 1498-1501
Copyright ©2001 by the American Physiological Society

Hippocampal Synaptic Transmission and Plasticity Are Preserved in Myosin Va Mutant Mice

Eric Schnell and Roger A. Nicoll

Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, California 94143

Schnell, Eric and Roger A. Nicoll. Hippocampal Synaptic Transmission and Plasticity Are Preserved in Myosin Va Mutant Mice. J. Neurophysiol. 85: 1498-1501, 2001. Recent studies have identified myosin Va as an organelle motor that may have important functions in neurons. Abundantly expressed at the hippocampal postsynaptic density, it interacts with protein complexes involved in synaptic plasticity. It is also located in presynaptic terminals and may function to recruit vesicles in the reserve pool to the active zone. Dilute-lethal mice are spontaneous myosin Va mutants and have severe neurological symptoms. We studied hippocampal physiology at CA3-CA1 excitatory synapses in dilute-lethal mutant mice to test the hypothesis that myosin Va plays a role in pre- or postsynaptic elements of synaptic transmission. In all assays performed, the mutant synapses appeared to be functioning normally, both pre- and postsynaptically. These data suggest that myosin Va is not essential for the synaptic release machinery, postsynaptic receptor composition, or plasticity at this synapse, but does not exclude significant roles for myosin Va in other cell types nor potential compensation by other myosin V isoforms.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
G. Srinivasan, J. H. Kim, and H. von Gersdorff
The Pool of Fast Releasing Vesicles Is Augmented by Myosin Light Chain Kinase Inhibition at the Calyx of Held Synapse
J Neurophysiol, April 1, 2008; 99(4): 1810 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Sloane and T. K. Vartanian
Myosin Va Controls Oligodendrocyte Morphogenesis and Myelination
J. Neurosci., October 17, 2007; 27(42): 11366 - 11375.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Desnos, S. Huet, I. Fanget, C. Chapuis, C. Bottiger, V. Racine, J.-B. Sibarita, J.-P. Henry, and F. Darchen
Myosin Va Mediates Docking of Secretory Granules at the Plasma Membrane
J. Neurosci., September 26, 2007; 27(39): 10636 - 10645.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Tokuoka and Y. Goda
Myosin Light Chain Kinase Is Not a Regulator of Synaptic Vesicle Trafficking during Repetitive Exocytosis in Cultured Hippocampal Neurons.
J. Neurosci., November 8, 2006; 26(45): 11606 - 11614.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-F. Lise, T. P. Wong, A. Trinh, R. M. Hines, L. Liu, R. Kang, D. J. Hines, J. Lu, J. R. Goldenring, Y. T. Wang, et al.
Involvement of Myosin Vb in Glutamate Receptor Trafficking
J. Biol. Chem., February 10, 2006; 281(6): 3669 - 3678.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Takagishi, S. Futaki, K. Itoh, E. M. Espreafico, N. Murakami, Y. Murata, and S. Mochida
Localization of myosin II and V isoforms in cultured rat sympathetic neurones and their potential involvement in presynaptic function
J. Physiol., November 15, 2005; 569(1): 195 - 208.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Kushner, Y. Elgersma, G. G. Murphy, D. Jaarsma, G. M. van Woerden, M. R. Hojjati, Y. Cui, J. C. LeBoutillier, D. F. Marrone, E. S. Choi, et al.
Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway
J. Neurosci., October 19, 2005; 25(42): 9721 - 9734.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Watanabe, K. Nomura, A. Ohyama, R. Ishikawa, Y. Komiya, K. Hosaka, E. Yamauchi, H. Taniguchi, N. Sasakawa, K. Kumakura, et al.
Myosin-Va Regulates Exocytosis through the Submicromolar Ca2+-dependent Binding of Syntaxin-1A
Mol. Biol. Cell, October 1, 2005; 16(10): 4519 - 4530.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. T. Libby, C. Lillo, J. Kitamoto, D. S. Williams, and K. P. Steel
Myosin Va is required for normal photoreceptor synaptic activity
J. Cell Sci., September 1, 2004; 117(19): 4509 - 4515.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
E. Pompili, A. De Luca, S. L. Nori, B. Maras, G. De Renzis, F. Ortolani, and L. Fumagalli
Biochemical and Immunohistochemical Evidence for a Non-muscle Myosin at the Neuromuscular Junction in Bovine Skeletal Muscle
J. Histochem. Cytochem., April 1, 2003; 51(4): 471 - 478.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Heidelberger, P. Sterling, and G. Matthews
Roles of ATP in Depletion and Replenishment of the Releasable Pool of Synaptic Vesicles
J Neurophysiol, July 1, 2002; 88(1): 98 - 106.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online