JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 85: 1543-1551, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (39)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bou-Flores, C.
Right arrow Articles by Berger, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bou-Flores, C.
Right arrow Articles by Berger, A. J.

The Journal of Neurophysiology Vol. 85 No. 4 April 2001, pp. 1543-1551
Copyright ©2001 by the American Physiological Society

Gap Junctions and Inhibitory Synapses Modulate Inspiratory Motoneuron Synchronization

Céline Bou-Flores and Albert J. Berger

Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195-7290

Bou-Flores, Céline and Albert J. Berger. Gap Junctions and Inhibitory Synapses Modulate Inspiratory Motoneuron Synchronization. J. Neurophysiol. 85: 1543-1551, 2001. Interneuronal electrical coupling via gap junctions and chemical synaptic inhibitory transmission are known to have roles in the generation and synchronization of activity in neuronal networks. Uncertainty exists regarding the roles of these two modes of interneuronal communication in the central respiratory rhythm-generating system. To assess their roles, we performed studies on both the neonatal mouse medullary slice and en bloc brain stem-spinal cord preparations where rhythmic inspiratory motor activity can readily be recorded from both hypoglossal and phrenic nerve roots. The rhythmic inspiratory activity observed had two temporal characteristics: the basic respiratory frequency occurring on a long time scale and the synchronous neuronal discharge within the inspiratory burst occurring on a short time scale. In both preparations, we observed that bath application of gap-junction blockers, including 18alpha -glycyrrhetinic acid, 18beta -glycyrrhetinic acid, and carbenoxolone, all caused a reduction in respiratory frequency. In contrast, peak integrated phrenic and hypoglossal inspiratory activity was not significantly changed by gap-junction blockade. On a short-time-scale, gap-junction blockade increased the degree of synchronization within an inspiratory burst observed in both nerves. In contrast, opposite results were observed with blockade of GABAA and glycine receptors. We found that respiratory frequency increased with receptor blockade, and simultaneous blockade of both receptors consistently resulted in a reduction in short-time-scale synchronized activity observed in phrenic and hypoglossal inspiratory bursts. These results support the concept that the central respiratory system has two components: a rhythm generator responsible for the production of respiratory cycle timing and an inspiratory pattern generator that is involved in short-time-scale synchronization. In the neonatal rodent, properties of both components can be regulated by interneuronal communication via gap junctions and inhibitory synaptic transmission.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Marchenko and R. F. Rogers
Time-frequency coherence analysis of phrenic and hypoglossal activity in the decerebrate rat during eupnea, hyperpnea, and gasping
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1430 - R1442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Y. Sebe, J. F. van Brederode, and A. J. Berger
Inhibitory Synaptic Transmission Governs Inspiratory Motoneuron Synchronization
J Neurophysiol, July 1, 2006; 96(1): 391 - 403.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Rabbah, J. Golowasch, and F. Nadim
Effect of Electrical Coupling on Ionic Current and Synaptic Potential Measurements
J Neurophysiol, July 1, 2005; 94(1): 519 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
B. Pfeuty, G. Mato, D. Golomb, and D. Hansel
The Combined Effects of Inhibitory and Electrical Synapses in Synchrony
Neural Comput., March 1, 2005; 17(3): 633 - 670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. H. O'Neal III, E. T. Spiegel, K. H. Chon, and I. C. Solomon
Time-Frequency Representation of Inspiratory Motor Output in Anesthetized C57BL/6 Mice In Vivo
J Neurophysiol, March 1, 2005; 93(3): 1762 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. K. Purvis and R. J. Butera
Ionic Current Model of a Hypoglossal Motoneuron
J Neurophysiol, February 1, 2005; 93(2): 723 - 733.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Putnam, J. A. Filosa, and N. A. Ritucci
Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1493 - C1526.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Kopell and B. Ermentrout
Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks
PNAS, October 26, 2004; 101(43): 15482 - 15487.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. M. St.-John and J. C. Leiter
High-frequency oscillations of phrenic activity in eupnea and gasping of in situ rat: influence of temperature
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R404 - R412.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Pfeuty, G. Mato, D. Golomb, and D. Hansel
Electrical Synapses and Synchrony: The Role of Intrinsic Currents
J. Neurosci., July 16, 2003; 23(15): 6280 - 6294.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. D. Traub, I. Pais, A. Bibbig, F. E. N. LeBeau, E. H. Buhl, S. G. Hormuzdi, H. Monyer, and M. A. Whittington
Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations
PNAS, February 4, 2003; 100(3): 1370 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. C. Solomon, K. H. Chon, and M. N. Rodriguez
Blockade of Brain Stem Gap Junctions Increases Phrenic Burst Frequency and Reduces Phrenic Burst Synchronization in Adult Rat
J Neurophysiol, January 1, 2003; 89(1): 135 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. B. Dean, D. Ballantyne, D. L. Cardone, J. S. Erlichman, and I. C. Solomon
Role of gap junctions in CO2 chemoreception and respiratory control
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L665 - L670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Marchenko, A. R. Granata, and M. I. Cohen
Respiratory cycle timing and fast inspiratory discharge rhythms in the adult decerebrate rat
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R931 - R940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Mutolo, F. Bongianni, M. Carfi, and T. Pantaleo
Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R227 - R242.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online