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The Journal of Neurophysiology Vol. 85 No. 4 April 2001, pp. 1732-1749
Copyright ©2001 by the American Physiological Society
1Coleman Memorial Laboratory and W. M. Keck Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143-0342; 2Departments of Neuroscience and Otolaryngology, University of Florida Brain Institute, Gainesville, Florida 32610-0244; and 3Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112-9458
Cheung, Steven W.,
Purvis H. Bedenbaugh,
Srikantan S. Nagarajan, and
Christoph E. Schreiner.
Functional Organization of Squirrel Monkey Primary Auditory
Cortex: Responses to Pure Tones. J. Neurophysiol. 85: 1732-1749, 2001. The spatial organization of response
parameters in squirrel monkey primary auditory cortex (AI) accessible
on the temporal gyrus was determined with the excitatory receptive
field to pure tone stimuli. Dense, microelectrode mapping of the
temporal gyrus in four animals revealed that characteristic frequency
(CF) had a smooth, monotonic gradient that systematically changed from lower values (0.5 kHz) in the caudoventral quadrant to higher values
(5-6 kHz) in the rostrodorsal quadrant. The extent of AI on the
temporal gyrus was ~4 mm in the rostrocaudal axis and 2-3 mm in the
dorsoventral axis. The entire length of isofrequency contours below 6 kHz was accessible for study. Several independent, spatially organized
functional response parameters were demonstrated for the squirrel
monkey AI. Latency, the asymptotic minimum arrival time for spikes with
increasing sound pressure levels at CF, was topographically organized
as a monotonic gradient across AI nearly orthogonal to the CF gradient.
Rostral AI had longer latencies (range = 4 ms). Threshold and
bandwidth co-varied with the CF. Factoring out the contribution of the
CF on threshold variance, residual threshold showed a monotonic
gradient across AI that had higher values (range = 10 dB)
caudally. The orientation of the threshold gradient was significantly
different from the CF gradient. CF-corrected bandwidth, residual Q10,
was spatially organized in local patches of coherent values whose loci
were specific for each monkey. These data support the existence of multiple, overlying receptive field gradients within AI and form the
basis to develop a conceptual framework to understand simple and
complex sound coding in mammals.
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