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The Journal of Neurophysiology Vol. 85 No. 4 April 2001, pp. 1782-1787
Copyright ©2001 by the American Physiological Society
RAPID COMMUNICATION
1Computational Neurobiology Laboratory, Howard Hughes Medical Institute, Sloan Center for Theoretical Neurobiology, The Salk Institute for Biological Studies, La Jolla 92037; and 2Division of Biology, Neurobiology Section, University of California, San Diego, La Jolla, California 92093
Fellous, J.-M.,
A. R. Houweling,
R. H. Modi,
R.P.N. Rao,
P.H.E. Tiesinga, and
T. J. Sejnowski.
Frequency Dependence of Spike Timing Reliability in Cortical
Pyramidal Cells and Interneurons. J. Neurophysiol. 85: 1782-1787, 2001. Pyramidal cells and interneurons in rat
prefrontal cortical slices exhibit subthreshold oscillations when
depolarized by constant current injection. For both types of neurons,
the frequencies of these oscillations for current injection just below
spike threshold were 2-10 Hz. Above spike threshold, however, the
subthreshold oscillations in pyramidal cells remained low, but the
frequency of oscillations in interneurons increased up to 50 Hz. To
explore the interaction between these intrinsic oscillations and
external inputs, the reliability of spiking in these cortical neurons
was studied with sinusoidal current injection over a range of
frequencies above and below the intrinsic frequency. Cortical neurons
produced 1:1 phase locking for a limited range of driving frequencies
for fixed amplitude. For low-input amplitude, 1:1 phase locking was obtained in the 5- to 10-Hz range. For higher-input amplitudes, pyramidal cells phase-locked in the 5- to 20-Hz range, whereas interneurons phase-locked in the 5- to 50-Hz range. For the amplitudes studied here, spike time reliability was always highest during 1:1
phase-locking, between 5 and 20 Hz for pyramidal cells and between 5 and 50 Hz for interneurons. The observed differences in the intrinsic
frequency preference between pyramidal cells and interneurons have
implications for rhythmogenesis and information transmission between
populations of cortical neurons.
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