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The Journal of Neurophysiology Vol. 86 No. 1 July 2001, pp. 528-532
Copyright ©2001 by the American Physiological Society
RAPID COMMUNICATION
Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112
Magee, Jeffrey C.
Dendritic Mechanisms of Phase Precession in Hippocampal CA1
Pyramidal Neurons. J. Neurophysiol. 86: 528-532, 2001. Dual whole-cell patch clamp recordings from the soma
and dendrites of CA1 pyramidal neurons located in hippocampal slices of
adult rats were used to examine the potential mechanisms of phase
precession. To mimic phasic synaptic input, 5-Hz sine wave current
injections were simultaneously delivered both to the soma and apical
dendrites (dendritic current was 180° out-of-phase with soma).
Increasing the amplitude of the dendritic current injection caused
somatic action potential initiation to advance in time (move forward up
to 180°). The exact pattern of phase advancement is dependent on the
dendritic location of input, with more distal input causing a more
gradual temporal shift in spike initiation and a smaller increase in
spike number. Patterned stimulation of Schaffer collateral/perforant
path synaptic input can produce phase precession that is very similar
to that observed with sine wave current injections. Finally, the exact
amount of synaptic input required to produce phase advancement was
found to be regulated by dendritic voltage-gated ion channels.
Together, these data demonstrate that the summation of primarily
proximal inhibition with an increasing amount of out-of-phase,
primarily distal excitation can result in a form of phase advancement
similar to that seen during theta activity in the intact hippocampus.
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