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The Journal of Neurophysiology Vol. 86 No. 2 August 2001, pp. 1062-1066
Copyright ©2001 by the American Physiological Society
RAPID COMMUNICATION
Department of Animal Physiology, University of Tübingen, D-72076 Tubingen, Germany
Gaese, Bernhard H. and
Joachim Ostwald.
Anesthesia Changes Frequency Tuning of Neurons in the Rat Primary
Auditory Cortex. J. Neurophysiol. 86: 1062-1066, 2001. The vast majority of investigations on central
auditory processing so far were conducted under the influence of an
anesthetic agent. It remains unclear, however, to what extend even
basic response properties of central auditory neurons are influenced by
this experimental manipulation. We used a combination of chronic recording in unrestrained animals, computer-controlled randomized acoustic stimulation, and statistical evaluation of responses to
directly compare the response characteristics of single neurons in the
awake and anesthetized state. Thereby we were able to quantify the
effects of pentobarbital/chloral hydrate anesthesia (Equithesin) on
rat auditory cortical neurons. During Equithesin anesthesia, only a
portion of central neurons were active and some of their basic response
properties were changed. Only 29% of the neurons still had a frequency
response area. Their tuning sharpness was increased under anesthesia.
Most changes are consistent with an enhancement of inhibitory
influences during Equithesin anesthesia. Thus when describing response
properties of central auditory neurons, the animal's anesthetic state
has to be taken into account.
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