JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 86: 662-675, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mustari, M. J.
Right arrow Articles by Livingston, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mustari, M. J.
Right arrow Articles by Livingston, C. A.

The Journal of Neurophysiology Vol. 86 No. 2 August 2001, pp. 662-675
Copyright ©2001 by the American Physiological Society

Gaze-Stabilizing Deficits and Latent Nystagmus in Monkeys With Early-Onset Visual Deprivation: Role of the Pretectal NOT

Michael J. Mustari,1 Ronald J. Tusa,1 Andrew F. Burrows,2 Albert F. Fuchs,3 and Christine A. Livingston2

 1Yerkes Regional Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322;  2Department of Anatomy and Neuroscience, University of Texas Medical Branch, Galveston, Texas 77555; and  3Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195

Mustari, Michael J., Ronald J. Tusa, Andrew F. Burrows, Albert F. Fuchs, and Christine A. Livingston. Gaze-Stabilizing Deficits and Latent Nystagmus in Monkeys With Early-Onset Visual Deprivation: Role of the Pretectal NOT. J. Neurophysiol. 86: 662-675, 2001. We studied the role of the pretectal nucleus of the optic tract (NOT) in the development of monocular optokinetic nystagmus (OKN) asymmetries and latent nystagmus (LN) in two monkeys reared with binocular deprivation (BD) caused by binocular eyelid suture for either the first 25 or 55 days of life. Single-unit recordings were performed in the right and left NOT of both monkeys at 2-3 yr of age and compared with similar unit recordings in normally reared monkeys. We also examined ocular motor behavior during electrical stimulation of the NOT and during pharmacological inactivation and activation using GABAA agonists and antagonists. In BD animals a large proportion of NOT units was dominated by the contralateral eye, in striking contrast to normal animals where 100% of NOT units were sensitive to stimuli delivered to either eye. In the 55-day BD animal no binocularly sensitive neurons were found, while in the 25-day BD animal 60% of NOT units retained at least some binocular sensitivity. Differences in direction sensitivity were also observed in BD animals. We found that 56% of units in the 55-day BD monkey and 10% of units in the 25-day BD monkey responded preferentially to contraversive visual motion. In contrast, only 5% of the NOT units encountered in normally reared monkeys respond preferentially during contraversive visual motion, the rest were most sensitive to ipsiversive visual motion. NOT neurons of BD monkeys showed a wide range of speed sensitivities similar to that of normal monkeys. Unilateral electrical stimulation of the NOT in BD animals induced a conjugate nystagmus with slow phases directed toward the side of stimulation. When we blocked the activity of NOT units with muscimol, a potent GABAA agonist, LN was abolished. In contrast, LN was increased when spontaneous activity of the NOT was enhanced with bicuculline, a GABAA antagonist. Our results indicate that the NOT in BD monkeys plays an important role in the OKN deficits and LN generation during monocular viewing. We hypothesize that the large proportion of units dominated by the contralateral eye contribute to the development of monocular OKN asymmetries and LN.




This article has been cited by other articles:


Home page
 IOVSHome page
M. Richards, A. Wong, P. Foeller, D. Bradley, and L. Tychsen
Duration of Binocular Decorrelation Predicts the Severity of Latent (Fusion Maldevelopment) Nystagmus in Strabismic Macaque Monkeys
Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1872 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. R. Economides, D. L. Adams, C. M. Jocson, and J. C. Horton
Ocular Motor Behavior in Macaques With Surgical Exotropia
J Neurophysiol, December 1, 2007; 98(6): 3411 - 3422.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ono and M. J. Mustari
Horizontal Smooth Pursuit Adaptation in Macaques After Muscimol Inactivation of the Dorsolateral Pontine Nucleus (DLPN)
J Neurophysiol, November 1, 2007; 98(5): 2918 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ono and M. J. Mustari
Extraretinal Signals in MSTd Neurons Related to Volitional Smooth Pursuit
J Neurophysiol, November 1, 2006; 96(5): 2819 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Sakai, H. Bi, I. Maruko, B. Zhang, J. Zheng, J. Wensveen, R. S. Harwerth, E. L. Smith III, and Y. M. Chino
Cortical Effects of Brief Daily Periods of Unrestricted Vision During Early Monocular Form Deprivation
J Neurophysiol, May 1, 2006; 95(5): 2856 - 2865.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. R. Economides and J. C. Horton
Eye movement abnormalities in stiff person syndrome
Neurology, November 8, 2005; 65(9): 1462 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. Watanabe, H. Bi, B. Zhang, E. Sakai, T. Mori, R. S. Harwerth, E. L. Smith III, and Y. M. Chino
Directional Bias of Neurons in V1 and V2 of Strabismic Monkeys: Temporal-to-Nasal Asymmetry?
Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3899 - 3905.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. M. Stewart, M. J. Mustari, and A. A. Perachio
Visual-Vestibular Interactions During Vestibular Compensation: Role of the Pretectal NOT in Horizontal VOR Recovery After Hemilabyrinthectomy in Rhesus Monkey
J Neurophysiol, October 1, 2005; 94(4): 2653 - 2666.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ono, V. E. Das, J. R. Economides, and M. J. Mustari
Modeling of Smooth Pursuit-Related Neuronal Responses in the DLPN and NRTP of the Rhesus Macaque
J Neurophysiol, January 1, 2005; 93(1): 108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ono, V. E. Das, and M. J. Mustari
Gaze-Related Response Properties of DLPN and NRTP Neurons in the Rhesus Macaque
J Neurophysiol, June 1, 2004; 91(6): 2484 - 2500.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
M. C. Brodsky and R. J. Tusa
Latent Nystagmus: Vestibular Nystagmus With a Twist
Arch Ophthalmol, February 1, 2004; 122(2): 202 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
M. J. MUSTARI, S. ONO, V. E. DAS, and R. J. TUSA
Role of the Dorsolateral Pontine Nucleus in Visual-Vestibular Behavior
Ann. N.Y. Acad. Sci., October 1, 2003; 1004(1): 196 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ono, V. E. Das, and M. J. Mustari
Role of the Dorsolateral Pontine Nucleus in Short-Term Adaptation of the Horizontal Vestibuloocular Reflex
J Neurophysiol, May 1, 2003; 89(5): 2879 - 2885.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
J. A. BUTTNER-ENNEVER, A.K. E. HORN, W. GRAF, and G. UGOLINI
Modern Concepts of Brainstem Anatomy: From Extraocular Motoneurons to Proprioceptive Pathways
Ann. N.Y. Acad. Sci., April 1, 2002; 956(1): 75 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
R. J. TUSA, M. J. MUSTARI, V. E. DAS, and R. G. BOOTHE
Animal Models for Visual Deprivation-Induced Strabismus and Nystagmus
Ann. N.Y. Acad. Sci., April 1, 2002; 956(1): 346 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
R. J. LEIGH, V. E. DAS, and S. H. SEIDMAN
A Neurobiological Approach to Acquired Nystagmus
Ann. N.Y. Acad. Sci., April 1, 2002; 956(1): 380 - 390.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Tusa, M. J. Mustari, A. F. Burrows, and A. F. Fuchs
Gaze-Stabilizing Deficits and Latent Nystagmus in Monkeys With Brief, Early-Onset Visual Deprivation: Eye Movement Recordings
J Neurophysiol, August 1, 2001; 86(2): 651 - 661.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online