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The Journal of Neurophysiology Vol. 86 No. 2 August 2001, pp. 856-870
Copyright ©2001 by the American Physiological Society
1Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013; and 2Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Craig, A. D. and
J. O. Dostrovsky.
Differential Projections of Thermoreceptive and Nociceptive
Lamina I Trigeminothalamic and Spinothalamic Neurons in the
Cat. J. Neurophysiol. 86: 856-870, 2001. The projections of 40 trigeminothalamic or spinothalamic (TSTT)
lamina I neurons were mapped using antidromic activation from a mobile
electrode array in barbiturate anesthetized cats. Single units were
identified as projection cells from the initial array position and
characterized with natural cutaneous stimuli as nociceptive-specific (NS, n = 9), polymodal nociceptive (HPC,
n = 8), or thermoreceptive-specific (COOL,
n = 22; WARM, n = 1) cells. Thresholds
for antidromic activation were measured from each electrode in the
mediolateral array at vertical steps of 250 µm over a 7-mm
dorsoventral extent in two to eight (median = 6.0) anteroposterior
planes. Histological reconstructions showed that the maps encompassed
all three of the main lamina I projection targets observed in prior
anatomical work, i.e., the ventral aspect of the ventroposterior
complex (vVP), the dorsomedial aspect of the ventroposterior medial
nucleus (dmVPM), and the submedial nucleus (Sm). The antidromic
activation foci were localized to these sites (and occasional
projections to other sites were also observed, such as the
parafascicular nucleus and zona incerta). The projections of
thermoreceptive and nociceptive cells differed. The projections of the
thermoreceptive-specific cells were 20/23 to dmVPM, 21/23 to vVP, and
17/23 to Sm, whereas the projections of the NS cells were 1/9 to dmVPM,
9/9 to vVP, and 9/9 to Sm and the projections of the HPC cells were 0/8
to dmVPM, 7/8 to vVP, and 6/8 to Sm. Thus nearly all thermoreceptive
cells projected to dmVPM, but almost no nociceptive cells did. Further,
thermoreceptive cells projected medially within vVP (including the
basal ventral medial nucleus), while nociceptive cells projected both
medially and more laterally, and the ascending axons of thermoreceptive cells were concentrated in the medial mesencephalon, while the axons of
nociceptive cells ascended in the lateral mesencephalon. These findings
provide evidence for anatomical differences between these physiological
classes of lamina I cells, and they corroborate prior anatomical
localization of the lamina I TSTT projection targets in the cat. These
results support evidence indicating that the ventral aspect of the
basal ventral medial nucleus is important for thermosensory behavior in
cats, consistent with the view that this region is a primordial
homologue of the posterior ventral medial nucleus in primates.
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