| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 86 No. 3 September 2001, pp. 1113-1130
Copyright ©2001 by the American Physiological Society
Center for Neural Science, New York University, New York, New York 10003
Malone, B. J. and
M. N. Semple.
Effects of Auditory Stimulus Context on the Representation of
Frequency in the Gerbil Inferior Colliculus. J. Neurophysiol. 86: 1113-1130, 2001. Prior studies of dynamic
conditioning have focused on modulation of binaural localization cues,
revealing that the responses of inferior colliculus (IC) neurons to
particular values of interaural phase and level disparities depend
critically on the context in which they occur. Here we show that
monaural frequency transitions, which do not simulate
azimuthal motion, also condition the responses of IC neurons. We
characterized single-unit responses to two frequency transition
stimuli: a glide stimulus comprising two tones linked by a linear
frequency sweep (origin-sweep-target) and a step stimulus consisting of
one tone followed immediately by another (origin-target). Using sets of
glide and step stimuli converging on a common target, we constructed
conditioned response functions (RFs) depicting the variability in the
response to an identical stimulus as a function of the preceding origin
frequency. For nearly all cells, the response to the target depended on
the origin frequency, even for origins outside the excitatory frequency
response area of the cell. Results from conditioned RFs based on long
(2-4 s) and short (200 ms) duration step stimuli indicate that
conditioning effects can be induced in the absence of the dynamic
sweep, and by stimuli of relatively short duration. Because IC neurons
are tuned to frequency, changes in the origin frequency often change the "effective" stimulus duty cycle. In many cases, the enhancement of the target response appeared related to the decrease in the "effective" stimulus duty cycle rather than to the prior
presentation of a particular origin frequency. Although this implies
that nonselective adaptive mechanisms are responsible for conditioned
responses, slightly more than half of IC neurons in each paradigm
responded significantly differently to targets following origins that
elicited statistically indistinguishable responses. The prevailing
influence of stimulus context when discharge history is controlled
demonstrates that not all the mechanisms governing conditioning depend
on the discharge history of the recorded neuron. Selective adaptation among the neuron's variously tuned afferents may help engender stimulus-specific conditioning. The demonstration that conditioning effects reflect sensitivity to spectral as well as spatial stimulus contrast has broad implications for the processing of a wide range of
dynamic acoustic signals and sound sequences.
This article has been cited by other articles:
|
|
 |
|
  B. Scholl, X. Gao, and M. Wehr Level Dependence of Contextual Modulation in Auditory Cortex J Neurophysiol, April 1, 2008; 99(4): 1616 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Reches and Y. Gutfreund Stimulus-Specific Adaptations in the Gaze Control System of the Barn Owl J. Neurosci., February 6, 2008; 28(6): 1523 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Malone, B. H. Scott, and M. N. Semple Dynamic Amplitude Coding in the Auditory Cortex of Awake Rhesus Macaques J Neurophysiol, September 1, 2007; 98(3): 1451 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ter-Mikaelian, D. H. Sanes, and M. N. Semple Transformation of Temporal Properties between Auditory Midbrain and Cortex in the Awake Mongolian Gerbil J. Neurosci., June 6, 2007; 27(23): 6091 - 6102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gutschalk, R. D. Patterson, M. Scherg, S. Uppenkamp, and A. Rupp The Effect of Temporal Context on the Sustained Pitch Response in Human Auditory Cortex Cereb Cortex, March 1, 2007; 17(3): 552 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gutfreund and E. I. Knudsen Adaptation in the Auditory Space Map of the Barn Owl J Neurophysiol, August 1, 2006; 96(2): 813 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Bartlett and X. Wang Long-Lasting Modulation by Stimulus Context in Primate Auditory Cortex J Neurophysiol, July 1, 2005; 94(1): 83 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Kvale and C. E. Schreiner Short-Term Adaptation of Auditory Receptive Fields to Dynamic Stimuli J Neurophysiol, February 1, 2004; 91(2): 604 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Ingham and D. McAlpine Spike-Frequency Adaptation in the Inferior Colliculus J Neurophysiol, February 1, 2004; 91(2): 632 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borisyuk, M. N. Semple, and J. Rinzel Adaptation and Inhibition Underlie Responses to Time-Varying Interaural Phase Cues in a Model of Inferior Colliculus Neurons J Neurophysiol, October 1, 2002; 88(4): 2134 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Malone, B. H. Scott, and M. N. Semple Context-Dependent Adaptive Coding of Interaural Phase Disparity in the Auditory Cortex of Awake Macaques J. Neurosci., June 1, 2002; 22(11): 4625 - 4638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. McAlpine and A. R. Palmer Blocking GABAergic Inhibition Increases Sensitivity to Sound Motion Cues in the Inferior Colliculus J. Neurosci., February 15, 2002; 22(4): 1443 - 1453. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
