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J Neurophysiol 86: 1131-1138, 2001;
0022-3077/01 $5.00
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The Journal of Neurophysiology Vol. 86 No. 3 September 2001, pp. 1131-1138
Copyright ©2001 by the American Physiological Society

Voltage-Sensitivity of Motoneuron NMDA Receptor Channels Is Modulated by Serotonin in the Neonatal Rat Spinal Cord

Jason N. MacLean and Brian J. Schmidt

Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3J7, Canada

MacLean, Jason N. and Brian J. Schmidt. Voltage-Sensitivity of Motoneuron NMDA Receptor Channels Is Modulated by Serotonin in the Neonatal Rat Spinal Cord. J. Neurophysiol. 86: 1131-1138, 2001. Both N-methyl-D-aspartate (NMDA) and serotonin (5-HT) receptors contribute to the generation of rhythmic motor patterns in the rat spinal cord. Co-application of these chemicals is more effective at producing locomotor-like activity than either neurochemical alone. In addition, NMDA application to rat spinal motoneurons, synaptically isolated in tetrodotoxin, induces nonlinear membrane behavior that results in voltage oscillations which can be blocked by 5-HT antagonists. However, the mechanisms underlying NMDA and 5-HT receptor interactions pertinent to motor rhythm production remain to be determined. In the present study, an in vitro neonatal rat spinal cord preparation was used to examine whether NMDA receptor-mediated nonlinear membrane voltage is modulated by 5-HT. Whole-cell recordings of spinal motoneurons demonstrated that 5-HT shifts the region of NMDA receptor-dependent negative slope conductance (RNSC) of the current-voltage relationship to more hyperpolarized potentials and enhances whole-cell inward current. The influence of 5-HT on the RNSC was similar to the effect on the RNSC of decreasing the extracellular Mg2+concentration. The results suggest that 5-HT may modulate this form of membrane voltage nonlinearity by regulating Mg2+ blockade of the NMDA ionophore.




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