JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 86: 1816-1825, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Otsuka, T.
Right arrow Articles by Song, W.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Otsuka, T.
Right arrow Articles by Song, W.-J.

The Journal of Neurophysiology Vol. 86 No. 4 October 2001, pp. 1816-1825
Copyright ©2001 by the American Physiological Society

Excitatory Postsynaptic Potentials Trigger a Plateau Potential in Rat Subthalamic Neurons at Hyperpolarized States

Takeshi Otsuka,1 Fujio Murakami,2,3 and Wen-Jie Song1

 1Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Suita 565-0871;  2Division of Biophysical Engineering, Graduate School of Engineering Science, Osaka University; and  3Core Research for Evolutional Science and Technology/Murakami Laboratory, Center for Advanced Research Projects, Osaka University, Toyonaka 560-8531, Japan

Otsuka, Takeshi, Fujio Murakami, and Wen-Jie Song. Excitatory Postsynaptic Potentials Trigger a Plateau Potential in Rat Subthalamic Neurons at Hyperpolarized States. J. Neurophysiol. 86: 1816-1825, 2001. The subthalamic nucleus (STN) directly innervates the output structures of the basal ganglia, playing a key role in basal ganglia function. It is therefore important to understand the regulatory mechanisms for the activity of STN neurons. In the present study, we aimed to investigate how the intrinsic membrane properties of STN neurons interact with their synaptic inputs, focusing on their generation and the properties of the long-lasting, plateau potential. Whole cell recordings were obtained from STN neurons in slices prepared from postnatal day 14 (P14) to P20 rats. We found that activation of glutamate receptor-mediated excitatory synaptic potentials (EPSPs) evoked a plateau potential in a subpopulation of STN neurons (n = 13/22), in a voltage-dependent manner. Plateau potentials could be induced only when the cell was hyperpolarized to more negative than about -75 mV. Plateau potentials, evoked with a depolarizing current pulse, again only from a hyperpolarized state, were observed in about half of STN neurons tested (n = 162/327). Only in neurons in which a plateau potential could be evoked by current injection did EPSPs evoke plateau potentials. L-type Ca2+ channels, Ca2+-dependent K+ channels, and TEA-sensitive K+ channels were found to be involved in the generation of the potential. The stability of the plateau potential, tested by the injection of a negative pulse current during the plateau phase, was found to be robust at the early phase of the potential, but decreased toward the end. As a result the early part of the plateau potential was resistant to membrane potential perturbations and would be able to support a train of action potentials. We conclude that excitatory postsynaptic potentials, evoked in a subpopulation of STN neurons at a hyperpolarized state, activate L-type Ca2+ and other channels, leading to the generation of a plateau potential. Thus about half of STN neurons can transform short-lasting synaptic excitation into a long train of output spikes by voltage-dependent generation of a plateau potential.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. Ramanathan, T. Tkatch, J. F. Atherton, C. J. Wilson, and M. D. Bevan
D2-Like Dopamine Receptors Modulate SKCa Channel Function in Subthalamic Nucleus Neurons Through Inhibition of Cav2.2 Channels
J Neurophysiol, February 1, 2008; 99(2): 442 - 459.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, and A. Benazzouz
Noradrenergic Modulation of Subthalamic Nucleus Activity: Behavioral and Electrophysiological Evidence in Intact and 6-Hydroxydopamine-Lesioned Rats
J. Neurosci., September 5, 2007; 27(36): 9595 - 9606.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. R. Lee and J. M. Tepper
A Calcium-Activated Nonselective Cation Conductance Underlies the Plateau Potential in Rat Substantia Nigra GABAergic Neurons
J. Neurosci., June 13, 2007; 27(24): 6531 - 6541.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. D. Humphries, R. D. Stewart, and K. N. Gurney
A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia
J. Neurosci., December 13, 2006; 26(50): 12921 - 12942.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K.-Z. Shen and S. W. Johnson
Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro
J. Physiol., June 15, 2006; 573(3): 697 - 709.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Gillies and D. Willshaw
Membrane Channel Interactions Underlying Rat Subthalamic Projection Neuron Rhythmic and Bursting Activity
J Neurophysiol, April 1, 2006; 95(4): 2352 - 2365.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. I. Kass and I. M. Mintz
Silent plateau potentials, rhythmic bursts, and pacemaker firing: Three patterns of activity that coexist in quadristable subthalamic neurons
PNAS, January 3, 2006; 103(1): 183 - 188.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. Baufreton, Z.-T. Zhu, M. Garret, B. Bioulac, S. W. Johnson, and A. I. Taupignon
Dopamine receptors set the pattern of activity generated in subthalamic neurons
FASEB J, November 1, 2005; 19(13): 1771 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. C Loucif, C. L Wilson, R Baig, M. G Lacey, and I. M Stanford
Functional interconnectivity between the globus pallidus and the subthalamic nucleus in the mouse brain slice
J. Physiol., September 15, 2005; 567(3): 977 - 987.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. J. Magill, A. Sharott, M. D. Bevan, P. Brown, and J. P. Bolam
Synchronous Unit Activity and Local Field Potentials Evoked in the Subthalamic Nucleus by Cortical Stimulation
J Neurophysiol, August 1, 2004; 92(2): 700 - 714.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Otsuka, T. Abe, T. Tsukagawa, and W.-J. Song
Conductance-Based Model of the Voltage-Dependent Generation of a Plateau Potential in Subthalamic Neurons
J Neurophysiol, July 1, 2004; 92(1): 255 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. E. Hallworth, C. J. Wilson, and M. D. Bevan
Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro
J. Neurosci., August 20, 2003; 23(20): 7525 - 7542.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Baufreton, M. Garret, A. Rivera, A. de la Calle, F. Gonon, B. Dufy, B. Bioulac, and A. Taupignon
D5 (Not D1) Dopamine Receptors Potentiate Burst-Firing in Neurons of the Subthalamic Nucleus by Modulating an L-Type Calcium Conductance
J. Neurosci., February 1, 2003; 23(3): 816 - 825.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online