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The Journal of Neurophysiology Vol. 86 No. 4 October 2001, pp. 1899-1907
Copyright ©2001 by the American Physiological Society
Howard Hughes Medical Institute and Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina 27710
McQuiston, A. Rory and
Lawrence C. Katz.
Electrophysiology of Interneurons in the Glomerular Layer of
the Rat Olfactory Bulb. J. Neurophysiol. 86: 1899-1907, 2001. In the mammalian olfactory bulb,
glomeruli are surrounded by a heterogeneous population of interneurons
called juxtaglomerular neurons. As they receive direct input from
olfactory receptor neurons and connect with mitral cells, they are
involved in the initial stages of olfactory information processing, but
little is known about their detailed physiological properties. Using whole cell patch-clamp techniques, we recorded from juxtaglomerular neurons in rat olfactory bulb slices. Based on their response to
depolarizing pulses, juxtaglomerular neurons could be divided into two
physiological classes: bursting and standard firing. When depolarized,
the standard firing neurons exhibited a range of responses:
accommodating, nonaccommodating, irregular firing, and delayed to
firing patterns of action potentials. Although the firing pattern was
not rigorously predictive of a particular neuronal morphology, most
short axon cells fired accommodating trains of action potentials, while
most delayed to firing cells were external tufted cells. In contrast to
the standard firing neurons, bursting neurons produced a
calcium-channel-dependent low-threshold spike when depolarized either
by current injection or by spontaneous or evoked postsynaptic
potentials. Bursting neurons also could oscillate spontaneously. Most
bursting cells were either periglomerular cells or external tufted
cells. Based on their mode of firing and placement in the bulb circuit,
these bursting cells are well situated to drive synchronous
oscillations in the olfactory bulb.
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