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The Journal of Neurophysiology Vol. 86 No. 4 October 2001, pp. 1991-2000
Copyright ©2001 by the American Physiological Society
1Graduate Program in Neuroscience, Siebens-Drake Research Institute, University of Western Ontario, London, Ontario N6G 2V4; 2Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2; 3Advanced Imaging Labs, The John P. Robarts Research Institute, London, Ontario N6A 5K8; 4Department of Physiology, University of Western Ontario, London, Ontario N6A 5C1, Canada; and 5Department of Physiology, Erasmus Universiteit Rotterdam, 3000 DR Rotterdam, The Netherlands
Dukelow, Sean P.,
Joseph F. X. DeSouza,
Jody C. Culham,
Albert V. van den
Berg,
Ravi S. Menon, and
Tutis Vilis.
Distinguishing Subregions of the Human MT+ Complex Using Visual
Fields and Pursuit Eye Movements. J. Neurophysiol. 86: 1991-2000, 2001. In humans, functional imaging
studies have demonstrated a homologue of the macaque motion complex,
MT+ [suggested to contain both middle temporal (MT) and medial
superior temporal (MST)], in the ascending limb of the inferior
temporal sulcus. In the macaque monkey, motion-sensitive areas MT and
MST are adjacent in the superior temporal sulcus. Electrophysiological
research has demonstrated that while MT receptive fields primarily
encode the contralateral visual field, MST dorsal (MSTd) receptive
fields extend well into the ipsilateral visual field. Additionally,
macaque MST has been shown to receive extraretinal smooth-pursuit
eye-movement signals, whereas MT does not. We used functional magnetic
resonance imaging (fMRI) and the neural properties that had been
observed in monkeys to distinguish putative human areas MT from MST.
Optic flow stimuli placed in the full field, or contralateral field only, produced a large cluster of functional activation in our subjects
consistent with previous reports of human area MT+. Ipsilateral optic
flow stimuli limited to the peripheral retina produced activation only
in an anterior subsection of the MT+ complex, likely corresponding to
putative MSTd. During visual pursuit of a single target, a large
portion of the MT+ complex was activated. However, during nonvisual
pursuit, only the anterolateral portion of the MT+ complex was
activated. This subsection of the MT+ cluster could correspond to
putative MSTl (lateral). In summary, we observed three distinct subregions of the human MT+ complex that were arranged in a manner similar to that seen in the monkey.
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