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The Journal of Neurophysiology Vol. 86 No. 4 October 2001, pp. 2029-2040
Copyright ©2001 by the American Physiological Society
1Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139; and 2Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School/MIT Division of Health Sciences and Technology, Boston, Massachusetts 02114
Frank, Loren M.,
Emery N. Brown, and
Matthew A. Wilson.
A Comparison of the Firing Properties of Putative Excitatory and
Inhibitory Neurons From CA1 and the Entorhinal Cortex. J. Neurophysiol. 86: 2029-2040, 2001. The
superficial layers of the entorhinal cortex (EC) provide the majority
of the neocortical input to the hippocampus, and the deep layers of the
EC receive the majority of neocortically bound hippocampal outputs. To
characterize information transmission through the hippocampal and EC
circuitry, we recorded simultaneously from neurons in the superficial
EC, the CA1 region of hippocampus, and the deep EC while rodents ran
for food reward in two environments. Spike waveform analysis allowed us
to classify units as fast-spiking (FS) putative inhibitory cells or
putative excitatory (PE) cells. PE and FS units' firing were often
strongly correlated at short time scales, suggesting the presence a
monosynaptic connection from the PE to FS units. EC PE units, unlike
those found in CA1, showed little or no tendency to fire in bursts. We
also found that the firing of FS and PE units from all regions was
modulated by the ~8 Hz theta rhythm, although the firing of deep EC
FS units tended to be less strongly modulated than that of the other
types of units. When we examined the spatial specificity of FS units, we determined that FS units in all three regions showed low
specificity. At the same time, retrospective coding, in which firing
rates were related to past position, was present in FS units from all three regions and deep EC FS units often fired in a "path
equivalent" manner in that they were active in physically different,
but behaviorally related positions both within and across environments.
Our results suggest that while the firing of FS units from CA1 and the
EC show similarly low levels of position specificity, FS units from each region differ from one another in that they mirrored the associated PE units in terms of their tendency to show more complex positional firing properties like retrospective coding and path equivalence.
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